ANKRD36 Antibody (E-4): sc-393764

ANKRD36 Antibody (E-4) is a mouse monoclonal IgG2a kappa light chain antibody that detects ANKRD36 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-ANKRD36 antibody (E-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ANKRD36, also known as ankyrin repeat domain 36 or ANKRD36A, is a 1,941 amino acid protein characterized by six ankyrin repeats and is part of the ankyrin repeat domain family. ANKRD36 plays a crucial role in cellular signaling and structural integrity by serving as a membrane adaptor that links integral membrane proteins to the spectrin-based cytoskeleton network. Proper functioning of ANKRD36 is vital, as mutations in ankyrin genes can lead to severe genetic disorders, including fatal cardiac arrhythmias and hereditary spherocytosis. ANKRD36 exists in four alternatively spliced isoforms and is encoded by a gene located on human chromosome 2q11.2. This chromosome is significant not only for its size, comprising approximately 8% of the human genome, but also for its potential involvement in genetic conditions, as translocations involving ANKRD36 have been associated with T-cell acute lymphoblastic leukemia. Understanding the structure and function of ANKRD36 is essential for elucidating its role in health and disease, making ANKRD36 (E-4) monoclonal antibody a valuable tool for researchers studying this important protein.

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ANKRD36 Antibody (E-4) References:

1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4.  |  Hillier, LW., et al. 2005. Nature. 434: 724-31. PMID: 15815621
2. Evidence for an ancestral alphoid domain on the long arm of human chromosome 2.  |  Avarello, R., et al. 1992. Hum Genet. 89: 247-9. PMID: 1587535
3. Spectrum of ALMS1 variants and evaluation of genotype-phenotype correlations in Alström syndrome.  |  Marshall, JD., et al. 2007. Hum Mutat. 28: 1114-23. PMID: 17594715
4. Compound heterozygous ABCA12 mutations including a novel nonsense mutation underlie harlequin ichthyosis.  |  Akiyama, M., et al. 2007. Dermatology. 215: 155-9. PMID: 17684380
5. Bone marrow ectopic expression of a non-coding RNA in childhood T-cell acute lymphoblastic leukemia with a novel t(2;11)(q11.2;p15.1) translocation.  |  Guastadisegni, MC., et al. 2008. Mol Cancer. 7: 80. PMID: 18947387
6. Origin of human chromosome 2: an ancestral telomere-telomere fusion.  |  IJdo, JW., et al. 1991. Proc Natl Acad Sci U S A. 88: 9051-5. PMID: 1924367

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ANKRD36 Antibody (E-4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ANKRD36 Antibody (E-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ANKRD36 Antibody (E-4) Specifications

Alternate Product Name: ANKRD36

Product Clone Name: E-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 70-99

Epitope Target: ANKRD36

Epitope Species: human

Product Reactivity/Detection: ANKRD36

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ANKRD36 Antibody (E-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin