Angptl2 Antibody (H-2): sc-393747
- Angptl2 Antibody (H-2) is a mouse monoclonal IgG1 κ Angptl2 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 158-254 mapping within an internal region of Angptl2 of human origin
- Angptl2 Antibody (H-2) is recommended for detection of Angptl2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Angptl2 Antibody (H-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Angptl2 Antibody (H-2) for WB applications. These reagents are now offered in bundles with Angptl2 Antibody (H-2) (see ordering information below).
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Angptl2 Antibody (H-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects Angptl2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Angptl2 antibody (H-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Angptl2, also known as angiopoietin-related protein 2 (ARP2), is a member of the fibrinogen superfamily and plays a crucial role in vascular biology. Angptl2 is predominantly expressed in adult heart, stomach, spleen, and small intestine tissues, and includes a conserved coiled-coil domain at the N-terminus, two glycosylation sites, and a fibrinogen-like domain at the C-terminus. These unique structural features are essential for Angptl2′s function in regulating angiogenesis, as Angptl2 does not act as a traditional growth factor but instead promotes endothelial cell sprouting through interactions with specific receptors. This mechanism is vital for proper vascular development, and dysregulated Angptl2 has been implicated in various pathological conditions, including diabetic glomerulopathy and tumor progression. Angptl2′s ability to mediate paracrine and autocrine signaling highlights its importance in both normal physiology and disease states, making Angptl2 (H-2) monoclonal antibody a valuable tool for researchers studying these processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Angptl2 Antibody (H-2) References:
- Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting. | Kim, I., et al. 1999. J Biol Chem. 274: 26523-8. PMID: 10473614
- Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis. | Kim, I., et al. 2000. Biochem J. 346 Pt 3: 603-10. PMID: 10698685
- Identification of human renal cell carcinoma associated genes by suppression subtractive hybridization. | Stassar, MJ., et al. 2001. Br J Cancer. 85: 1372-82. PMID: 11720477
- Inhibition of angiogenesis and vascular leakiness by angiopoietin-related protein 4. | Ito, Y., et al. 2003. Cancer Res. 63: 6651-7. PMID: 14583458
- Cooperative interaction of Angiopoietin-like proteins 1 and 2 in zebrafish vascular development. | Kubota, Y., et al. 2005. Proc Natl Acad Sci U S A. 102: 13502-7. PMID: 16174743
- Angiopoietin-like proteins: another player in the metabolic field. | George, J. 2006. J Hepatol. 44: 832-4. PMID: 16488509
- Extracellular matrix-bound angiopoietin-like 4 inhibits endothelial cell adhesion, migration, and sprouting and alters actin cytoskeleton. | Cazes, A., et al. 2006. Circ Res. 99: 1207-15. PMID: 17068295
- In situ identification of genes regulated specifically in fibroblasts of human basal cell carcinoma. | Micke, P., et al. 2007. J Invest Dermatol. 127: 1516-23. PMID: 17273163
- Enhanced expression of ANGPTL2 in the microvascular lesions of diabetic glomerulopathy. | Sun, H., et al. 2007. Nephron Exp Nephrol. 105: e117-23. PMID: 17347581
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Angptl2 Antibody (H-2) | sc-393747 | 200 µg/ml | $316.00 | |||
Angptl2 Antibody (H-2): m-IgG Fc BP-HRP Bundle | sc-527710 | 200 µg Ab; 10 µg BP | $354.00 | |||
Angptl2 Antibody (H-2): m-IgG1 BP-HRP Bundle | sc-533083 | 200 µg Ab; 20 µg BP | $354.00 | |||
Angptl2 Antibody (H-2) AC | sc-393747 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Angptl2 Antibody (H-2) HRP | sc-393747 HRP | 200 µg/ml | $316.00 | |||
Angptl2 Antibody (H-2) FITC | sc-393747 FITC | 200 µg/ml | $330.00 | |||
Angptl2 Antibody (H-2) PE | sc-393747 PE | 200 µg/ml | $343.00 | |||
Angptl2 Antibody (H-2) Alexa Fluor® 488 | sc-393747 AF488 | 200 µg/ml | $357.00 | |||
Angptl2 Antibody (H-2) Alexa Fluor® 546 | sc-393747 AF546 | 200 µg/ml | $357.00 | |||
Angptl2 Antibody (H-2) Alexa Fluor® 594 | sc-393747 AF594 | 200 µg/ml | $357.00 | |||
Angptl2 Antibody (H-2) Alexa Fluor® 647 | sc-393747 AF647 | 200 µg/ml | $357.00 | |||
Angptl2 Antibody (H-2) Alexa Fluor® 680 | sc-393747 AF680 | 200 µg/ml | $357.00 | |||
Angptl2 Antibody (H-2) Alexa Fluor® 790 | sc-393747 AF790 | 200 µg/ml | $357.00 |