AMPKβ2 Antibody (362-7): sc-100358
- AMPKβ2 Antibody (362-7) is a mouse monoclonal IgG2b κ provided at 100 µg/ml
- raised against recombinant AMPKβ2 of human origin
- recommended for detection of AMPKβ2 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for AMPKβ2 Antibody (362-7). This work is in progress.
AMPKβ2 Antibody (362-7) is a mouse monoclonal IgG2b antibody that detects AMPKβ2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). AMPKβ2 is a crucial regulatory subunit of the 5′-AMP-activated protein kinase (AMPK) complex, which plays a vital role in cellular energy homeostasis. AMPKβ2 is primarily located in the cytoplasm and is essential for the proper functioning of AMPK, as AMPKβ2 helps to stabilize the complex and facilitate activation in response to energy stress. AMPKβ2′s presence in the cytoplasm allows for rapid signaling in response to fluctuations in cellular energy levels, enabling the cell to adapt metabolic pathways accordingly. By promoting the phosphorylation of key enzymes involved in lipid and glucose metabolism, AMPKβ2 contributes to the regulation of energy balance, making AMPKβ2 a significant player in metabolic disorders such as obesity and diabetes. AMPKβ2 consists of 272 amino acids and interacts with the catalytic α subunit and the γ subunit, forming a heterotrimeric complex essential for kinase activity. AMPKβ2′s ability to modulate energy expenditure and metabolic processes underscores AMPKβ2′s importance in maintaining cellular health and responding to metabolic challenges.
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AMPKβ2 Antibody (362-7) References:
- Role of the alpha2-isoform of AMP-activated protein kinase in the metabolic response of the heart to no-flow ischemia. | Zarrinpashneh, E., et al. 2006. Am J Physiol Heart Circ Physiol. 291: H2875-83. PMID: 16877552
- Control of glycogen synthase through ADIPOR1-AMPK pathway in renal distal tubules of normal and diabetic rats. | Cammisotto, PG., et al. 2008. Am J Physiol Renal Physiol. 294: F881-9. PMID: 18256313
- Sumoylation of AMPKβ2 subunit enhances AMP-activated protein kinase activity. | Rubio, T., et al. 2013. Mol Biol Cell. 24: 1801-11, S1-4. PMID: 23552691
- AMPKβ subunits: more than just a scaffold in the formation of AMPK complex. | Sanz, P., et al. 2013. FEBS J. 280: 3723-33. PMID: 23721051
- AMP-activated protein kinase complexes containing the β2 regulatory subunit are up-regulated during and contribute to adipogenesis. | Katwan, OJ., et al. 2019. Biochem J. 476: 1725-1740. PMID: 31189568
- Niclosamide activates the AMP-activated protein kinase complex containing the β2 subunit independently of AMP. | Suzuki, T., et al. 2020. Biochem Biophys Res Commun. 533: 758-763. PMID: 32993962
- TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy. | Wu, W., et al. 2021. Autophagy. 17: 3992-4009. PMID: 33779513
- Skeletal muscle cell-specific differences in type 2 diabetes. | Frankenberg, NT., et al. 2022. Cell Mol Life Sci. 79: 256. PMID: 35460430
- AMP-activated protein kinase β1 or β2 deletion enhances colon cancer cell growth and tumorigenesis. | Shi, F., et al. 2022. Acta Biochim Biophys Sin (Shanghai). 54: 1140-1147. PMID: 35880569
- Suppression of neuronal AMPKβ2 isoform impairs recognition memory and synaptic plasticity. | Swift, NA., et al. 2024. Neurobiol Dis. 201: 106664. PMID: 39278510
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AMPKβ2 Antibody (362-7) | sc-100358 | 100 µg/ml | $339.00 |