AMPD2 Antibody (QQ13): sc-100504

AMPD2 Antibody (QQ13) is a mouse monoclonal IgG1 kappa light chain antibody that detects human AMPD2 by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-AMPD2 antibody (QQ13) is available as a non-conjugated monoclonal isotype antibody. AMPD2, also known as liver-type AMP deaminase, plays a crucial role in energy metabolism by catalyzing the hydrolytic deamination of adenosine monophosphate (AMP) to inosine monophosphate (IMP) and ammonia. This enzymatic activity is vital for the purine nucleotide cycle, which is essential for cellular energy homeostasis. AMPD2 functions as a homotetramer and is predominantly expressed in undifferentiated myoblasts, smooth muscle, embryonic muscle, and various non-muscle tissues, distinguishing AMPD2 from isozymes AMPD1 and AMPD3, which are found in skeletal muscle and erythrocytes, respectively. Multiple isoforms of AMPD2, resulting from alternative splicing, highlight the complexity of regulation and function in different tissues, making AMPD2 an important target for studies related to energy metabolism and muscle physiology.

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AMPD2 Antibody (QQ13) References:

1. Initiation of DNA replication at the Chinese hamster origin oriGNAI3 relies on local sequences and/or chromatin structures, but not on transcription of the nearby GNAI3 gene.  |  Toledo, F., et al. 1999. Nucleic Acids Res. 27: 1600-8. PMID: 10075990
2. Localization of N-terminal sequences in human AMP deaminase isoforms that influence contractile protein binding.  |  Mahnke-Zizelman, DK. and Sabina, RL. 2001. Biochem Biophys Res Commun. 285: 489-95. PMID: 11444869
3. Expression, purification, and inhibition of in vitro proteolysis of human AMPD2 (isoform L) recombinant enzymes.  |  Haas, AL. and Sabina, RL. 2003. Protein Expr Purif. 27: 293-303. PMID: 12597889
4. N-terminal extensions of the human AMPD2 polypeptide influence ATP regulation of isoform L.  |  Haas, AL. and Sabina, RL. 2003. Biochem Biophys Res Commun. 305: 421-7. PMID: 12745092
5. Full-size form of human liver AMP-deaminase?  |  Szydlowska, M., et al. 2004. Mol Cell Biochem. 266: 133-7. PMID: 15646034
6. Expression patterns of AMP-deaminase and cytosolic 5'-nucleotidase genes in human term placenta.  |  Roszkowska, A., et al. 2008. Mol Cell Biochem. 311: 249-51. PMID: 18165923
7. Characterization of human AMP deaminase 2 (AMPD2) gene expression reveals alternative transcripts encoding variable N-terminal extensions of isoform L.  |  Van den Bergh, F. and Sabina, RL. 1995. Biochem J. 312 (Pt 2): 401-10. PMID: 8526848
8. Cloning, sequence and characterization of the human AMPD2 gene: evidence for transcriptional regulation by two closely spaced promoters.  |  Mahnke-Zizelman, DK., et al. 1996. Biochim Biophys Acta. 1308: 122-32. PMID: 8764830
9. Regulation of rat AMP deaminase 3 (isoform C) by development and skeletal muscle fibre type.  |  Mahnke-Zizelman, DK., et al. 1997. Biochem J. 326 (Pt 2): 521-9. PMID: 9291127

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-AMPD2 Antibody (QQ13) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-AMPD2 Antibody (QQ13) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

AMPD2 Antibody (QQ13) Specifications

Alternate Product Name: AMPD2

Product Clone Name: QQ13

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 86-186

Epitope Target: AMPD2

Epitope Species: human

Product Reactivity/Detection: AMPD2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 50 µg IgG₁ kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for AMPD2 Antibody (QQ13): N/A