Aminopeptidase A Antibody (FG35.4): sc-52444

Aminopeptidase A Antibody (FG35.4) is a rat monoclonal IgG1 antibody that detects Aminopeptidase A of mouse origin by immunoprecipitation (IP) and flow cytometry (FCM). Anti-Aminopeptidase A antibody (FG35.4) is available in both non-conjugated and various conjugated forms, including phycoerythrin (PE). Aminopeptidase A, also known as APA, gp160 human kidney differentiation antigen, glutamyl aminopeptidase, or enpep, is a crucial differentiation-related glycoprotein found on the surface of epithelial cells in the glomerulus and proximal tubule cells of the human nephron. Aminopeptidase A functions as a zinc-dependent metalloprotease, specifically cleaving amino-terminal acidic residues from peptide substrates such as Angiotensin II, which plays a significant role in regulating blood pressure and fluid balance. Aminopeptidase A is vital for the constitutive trafficking of Glut4-containing vesicles, which are essential for insulin-dependent translocation of GLUT4 to the cell surface in adipose and muscle tissues. Mutations in the gp160/APA gene, including loss of protein expression or enzymatic activity, have been identified in approximately 20% of primary clear cell renal carcinomas, highlighting Aminopeptidase A′s importance in both normal physiology and disease states.

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Aminopeptidase A Antibody (FG35.4) References:

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7. The major protein of GLUT4-containing vesicles, gp160, has aminopeptidase activity.  |  Kandror, KV., et al. 1994. J Biol Chem. 269: 30777-80. PMID: 7983006
8. Widespread tissue distribution of aminopeptidase A, an evolutionarily conserved ectoenzyme recognized by the BP-1 antibody.  |  Li, L., et al. 1993. Tissue Antigens. 42: 488-96. PMID: 8146860
9. Molecular cloning of the human kidney differentiation antigen gp160: human aminopeptidase A.  |  Nanus, DM., et al. 1993. Proc Natl Acad Sci U S A. 90: 7069-73. PMID: 8346219
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11. Aminopeptidase A expression and enzymatic activity in primary human renal cancers.  |  Nanus, DM., et al. 1998. Int J Oncol. 13: 261-7. PMID: 9664120