AMIGO2 Antibody (G-7): sc-373699

AMIGO2 Antibody (G-7) is a mouse monoclonal IgA kappa light chain antibody that detects AMIGO2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-AMIGO2 antibody (G-7) is available as the non-conjugated form. AMIGO2, a member of the amphoterin-induced gene and ORF (AMIGO) family, plays a critical role in the development and maintenance of neuronal tissues. AMIGO2 is primarily located in the plasma membrane of neurons, where AMIGO2 facilitates cell-cell interactions and signaling pathways essential for neuronal growth and survival. AMIGO2 presence in neuronal fiber tracts underscores AMIGO2′s importance in the formation and stabilization of these structures, which are vital for proper neural function. Additionally, AMIGO2 interacts with other members of the AMIGO family, such as AMIGO-1 and AMIGO-3, enhancing AMIGO2′s role in promoting neurite outgrowth and myelination. AMIGO2′s ability to mediate these interactions is crucial for the development of the nervous system and for maintaining the integrity of neural networks, making AMIGO2 a significant target for research in neurobiology and related fields.

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AMIGO2 Antibody (G-7) References:

1. AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats.  |  Kuja-Panula, J., et al. 2003. J Cell Biol. 160: 963-73. PMID: 12629050
2. Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons.  |  Ono, T., et al. 2003. J Neurosci. 23: 5887-96. PMID: 12843293
3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.  |  Clark, HF., et al. 2003. Genome Res. 13: 2265-70. PMID: 12975309
4. AMIGO and friends: an emerging family of brain-enriched, neuronal growth modulating, type I transmembrane proteins with leucine-rich repeats (LRR) and cell adhesion molecule motifs.  |  Chen, Y., et al. 2006. Brain Res Rev. 51: 265-74. PMID: 16414120
5. In vivo selection of highly metastatic human ovarian cancer sublines reveals role for AMIGO2 in intra-peritoneal metastatic regulation.  |  Liu, Y., et al. 2021. Cancer Lett. 503: 163-173. PMID: 33524500
6. Single-cell transcriptome and genome analyses of pituitary neuroendocrine tumors.  |  Cui, Y., et al. 2021. Neuro Oncol. 23: 1859-1871. PMID: 33908609
7. AMIGO2 attenuates innate cisplatin sensitivity by suppression of GSDME-conferred pyroptosis in non-small cell lung cancer.  |  Chen, LK., et al. 2023. J Cell Mol Med. 27: 2412-2423. PMID: 37438979
8. AMIGO2 is a pivotal therapeutic target related to M2 polarization of macrophages in pancreatic ductal adenocarcinoma.  |  Chen, S., et al. 2024. Aging (Albany NY). 16: 1111-1127. PMID: 38189855
9. AMIGO2 is involved in the spread of peritoneal metastasis in serous ovarian cancer via promoting adhesion to the peritoneal mesothelial cells.  |  Iida, Y., et al. 2024. Int J Clin Oncol. 29: 1354-1363. PMID: 38811439
10. Knockdown of AMIGO2 suppresses proliferation and migration through regulating PPAR-γ in bladder cancer.  |  Han, D., et al. 2024. Hereditas. 161: 21. PMID: 38978149
11. A Targetable Secreted Neural Protein Drives Pancreatic Cancer Metastatic Colonization and HIF1α Nuclear Retention.  |  Yamaguchi, N., et al. 2024. Cancer Discov. 14: 2489-2508. PMID: 39028915
12. AMIGO2 enhances the invasive potential of colorectal cancer by inducing EMT.  |  Izutsu, R., et al. 2024. Cancer Gene Ther. 31: 1786-1795. PMID: 39379686

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-AMIGO2 Antibody (G-7) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-AMIGO2 Antibody (G-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

AMIGO2 Antibody (G-7) Specifications

Alternate Product Name: AMIGO2

Product Clone Name: G-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgA kappa light chain

Amino Acids: 142-171

Epitope Target: AMIGO2

Epitope Species: human

Product Reactivity/Detection: AMIGO2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgA kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for AMIGO2 Antibody (G-7): P: Blocking Peptide