Molecular structure of AMD3100 octahydrochloride, CAS Number: 155148-31-5
AMD3100 octahydrochloride (CAS 155148-31-5)
See product citations (19)
Alternate Names:
1,1′-(1,4-Phenylenebis(methylene))bis-1,4,8,11-tetraazacyclotetradecane octahydrochloride
Application:
AMD3100 octahydrochloride is a specific CXCR4 antagonist
CAS Number:
155148-31-5
Purity:
≥98%
Molecular Weight:
794.47
Molecular Formula:
C28H54N8•8HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
AMD3100 octahydrochloride is a selective bicyclam derivative which functions as a stem cell mobiliser via blocking the CXCR4 chemokine receptor. Studies suggest that AMD3100 octahydrochloride causes the rapid movement of stem cells out of bone marrow via blocking the CXCR4 receptor. Since the CXCR4 receptor is responsible for regulating metastasis in chemoresistant melanoma cells, blocking this receptor can possibly reduce the metastasis of melanoma cells. In addition, studies indicate that AMD3100 octahydrochloride can inhibit the replication of human immunodeficiency virus in vitro by blocking the entry of the virus into cells. Furthermore, AMD3100 octahydrochloride can also reduce the number of human CD4+ T cells.
AMD3100 octahydrochloride (CAS 155148-31-5) References
- Migration from a mitogenic niche promotes cell-cycle exit. | Choi, Y., et al. 2005. J Neurosci. 25: 10437-45. PMID: 16280582
- The Galpha13-Rho signaling axis is required for SDF-1-induced migration through CXCR4. | Tan, W., et al. 2006. J Biol Chem. 281: 39542-9. PMID: 17056591
- Plerixafor: AMD 3100, AMD3100, JM 3100, SDZ SID 791. | . 2007. Drugs R D. 8: 113-9. PMID: 17324009
- CXCL12-CXCR4 signalling axis confers gemcitabine resistance to pancreatic cancer cells: a novel target for therapy. | Singh, S., et al. 2010. Br J Cancer. 103: 1671-9. PMID: 21045835
- CXCR4 signaling regulates metastasis of chemoresistant melanoma cells by a lymphatic metastatic niche. | Kim, M., et al. 2010. Cancer Res. 70: 10411-21. PMID: 21056990
- Effects of mesenchymal stem cell-derived cytokines on the functional properties of endothelial progenitor cells. | Kamprom, W., et al. 2016. Eur J Cell Biol. 95: 153-63. PMID: 26899034
- Antitumor effect of CXCR4 antagonist AMD3100 on the tumorigenic cell line of BHP10-3 papillary thyroid cancer cells. | Jung, YH., et al. 2016. Head Neck. 38: 1479-86. PMID: 27061747
- SOX11 promotes tumor protective microenvironment interactions through CXCR4 and FAK regulation in mantle cell lymphoma. | Balsas, P., et al. 2017. Blood. 130: 501-513. PMID: 28533307
- CXCR4 antagonist delivery on decellularized skin scaffold facilitates impaired wound healing in diabetic mice by increasing expression of SDF-1 and enhancing migration of CXCR4-positive cells. | Liu, H., et al. 2017. Wound Repair Regen. 25: 652-664. PMID: 28783870
- Pleiotrophin: Analysis of the endothelialisation potential. | Copes, F., et al. 2019. Adv Med Sci. 64: 144-151. PMID: 30660899
- Development and Evaluation of 1'-Acetoxychavicol Acetate (ACA)-Loaded Nanostructured Lipid Carriers for Prostate Cancer Therapy. | Subramaniam, B., et al. 2021. Pharmaceutics. 13: PMID: 33804975
- Targeted blockade of immune mechanisms inhibit B precursor acute lymphoblastic leukemia cell invasion of the central nervous system. | Rajakumar, SA., et al. 2021. Cell Rep Med. 2: 100470. PMID: 35028611
- Brain motor and fear circuits regulate leukocytes during acute stress. | Poller, WC., et al. 2022. Nature. 607: 578-584. PMID: 35636458
- Antiviral efficacy in vivo of the anti-human immunodeficiency virus bicyclam SDZ SID 791 (JM 3100), an inhibitor of infectious cell entry. | Datema, R., et al. 1996. Antimicrob Agents Chemother. 40: 750-4. PMID: 8851605
Inhibitor of:
CXCR-4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AMD3100 octahydrochloride, 5 mg | sc-252367 | 5 mg | $92.00 |