AMD3100 octahydrochloride is a selective bicyclam derivative which functions as a stem cell mobiliser via blocking the CXCR4 chemokine receptor. Studies suggest that AMD3100 octahydrochloride causes the rapid movement of stem cells out of bone marrow via blocking the CXCR4 receptor. Since the CXCR4 receptor is responsible for regulating metastasis in chemoresistant melanoma cells, blocking this receptor can possibly reduce the metastasis of melanoma cells. In addition, studies indicate that AMD3100 octahydrochloride can inhibit the replication of human immunodeficiency virus in vitro by blocking the entry of the virus into cells. Furthermore, AMD3100 octahydrochloride can also reduce the number of human CD4+ T cells.
1. Datema, R., et al., 1996. Antiviral efficacy in vivo of the anti-human immunodeficiency virus bicyclam SDZ SID 791 (JM 3100), an inhibitor of infectious cell entry. Antimicrobial agents and chemotherapy. 40(3): 750-4. PMID: 8851605
2. , ., et al., 2007. Plerixafor: AMD 3100, AMD3100, JM 3100, SDZ SID 791. Drugs in R&D. 8(2): 113-9. PMID: 17324009
3. Kim, Minah., et al., 2010. CXCR4 signaling regulates metastasis of chemoresistant melanoma cells by a lymphatic metastatic niche. Cancer research. 70(24): 10411-21. PMID: 21056990
See how others have used AMD3100 octahydrochloride (CAS 155148-31-5). Click on the entry to view the PubMed entry .
PMID: # 25351811 Li, X. et al. 2015. Biotechnology letters. 37: 511-21.
PMID: # 24085800 Wang, B. et al. 2014. Carcinogenesis. 35: 282-91.
PMID: # 25157648 Wang, Y. et al. 2014. Molecular pharmaceutics. 11: 3463-70.
PMID: # 22688512 Asano, S. et al. 2012. Molecular and cellular biology. 32: 3242-52.
PMID: # 21850188 Liu, G. et al. 2011. Mol. Vis. 17: 2129-2138.
PMID: # 32154067 Adv Sci (Weinh). 7: 1901866.
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