AMCase Antibody (E-11): sc-365676

AMCase Antibody (E-11) is a mouse monoclonal IgM antibody that detects AMCase protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-AMCase antibody (E-11) is available as the non-conjugated form. Acidic mammalian chitinase precursor (AMCase) plays a crucial role in degrading chitin and chitooligosaccharides, which are important for immune response against chitin-containing pathogens. AMCase (E-11) antibody recognizes a protein predominantly expressed in the stomach, where AMCase contributes to dietary chitin breakdown, facilitating nutrient absorption and maintaining gut health. AMCase is secreted into the extracellular space, where AMCase can interact with various substrates, highlighting AMCase importance in both digestive processes and potential therapeutic applications in conditions such as asthma and allergic diseases, where Th2-mediated inflammation is a factor. AMCase ability to modulate immune responses makes AMCase a significant target for research into chitinase-related disorders and therapies.

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AMCase Antibody (E-11) References:

1. Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation.  |  Zhu, Z., et al. 2004. Science. 304: 1678-82. PMID: 15192232
2. Plasma chitotriosidase and CCL18: early biochemical surrogate markers in type B Niemann-Pick disease.  |  Brinkman, J., et al. 2005. J Inherit Metab Dis. 28: 13-20. PMID: 15702402
3. Identification and use of biomarkers in Gaucher disease and other lysosomal storage diseases.  |  Aerts, JM., et al. 2005. Acta Paediatr Suppl. 94: 43-6; discussion 37-8. PMID: 15895711
4. Clinical evaluation of biomarkers in Gaucher disease.  |  Deegan, PB. and Cox, TM. 2005. Acta Paediatr Suppl. 94: 47-50; discussion 37-8. PMID: 15895712
5. Effect of interferon-gamma, interleukin-10, lipopolysaccharide and tumor necrosis factor-alpha on chitotriosidase synthesis in human macrophages.  |  Di Rosa, M., et al. 2005. Clin Chem Lab Med. 43: 499-502. PMID: 15899671
6. Interferon-gamma, tumor necrosis factor-alpha, and lipopolysaccharide promote chitotriosidase gene expression in human macrophages.  |  Malaguarnera, L., et al. 2005. J Clin Lab Anal. 19: 128-32. PMID: 15900564
7. Marked differences in tissue-specific expression of chitinases in mouse and man.  |  Boot, RG., et al. 2005. J Histochem Cytochem. 53: 1283-92. PMID: 15923370
8. Kinetic characterization of recombinant human acidic mammalian chitinase.  |  Chou, YT., et al. 2006. Biochemistry. 45: 4444-54. PMID: 16584180

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-AMCase Antibody (E-11) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-AMCase Antibody (E-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

AMCase Antibody (E-11) Specifications

Alternate Product Name: AMCase

Product Clone Name: E-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 168-214

Epitope Target: AMCase

Epitope Species: human

Product Reactivity/Detection: AMCase

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for AMCase Antibody (E-11): N/A