Molecular structure of Ambenonium dichloride, CAS Number: 52022-31-8
Ambenonium dichloride (CAS 52022-31-8)
Alternate Names:
N,N′-[(1,2-Dioxo-1,2-ethanediyl)bis( imino-2,1-ethanediyl)]bis(2-chloro-N,N-diethylbenz enemethaminium) dichloride
Application:
Ambenonium dichloride is a selective, potent and rapid reversible inhibitor of AChE
CAS Number:
52022-31-8
Molecular Weight:
608.48
Molecular Formula:
C28H42Cl2N4O2•Cl2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ambenonium dichloride is the dichloride salt of Ambenonium, a selective inhibitor of acetylcholine esterase (AChE). Ambenonium is described to be a rapidly reversible noncovalent inhibitor of AChE, demonstrating high affinity (IC50 = 0.698 nM) at AChE and a lower affinity (IC50 = 8.20 μM) at BChE (butyrylcholine esterase).
Ambenonium dichloride (CAS 52022-31-8) References
- Design, synthesis and biological evaluation of ambenonium derivatives as AChE inhibitors. | Bolognesi, ML., et al. 2003. Farmaco. 58: 917-28. PMID: 13679187
- Ambenonium is a rapidly reversible noncovalent inhibitor of acetylcholinesterase, with one of the highest known affinities. | Hodge, AS., et al. 1992. Mol Pharmacol. 41: 937-42. PMID: 1588924
- Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage--implications for early Myasthenia gravis treatment. | Musilek, K., et al. 2011. Eur J Med Chem. 46: 811-8. PMID: 21236521
- Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors--implications for early myasthenia gravis treatment. | Komloova, M., et al. 2011. Bioorg Med Chem Lett. 21: 2505-9. PMID: 21397501
- Preparation, in vitro evaluation and molecular modelling of pyridinium-quinolinium/isoquinolinium non-symmetrical bisquaternary cholinesterase inhibitors. | Komloova, M., et al. 2013. Bioorg Med Chem Lett. 23: 6663-6. PMID: 24220173
- Profiling the Tox21 Chemical Collection for Acetylcholinesterase Inhibition. | Li, S., et al. 2021. Environ Health Perspect. 129: 47008. PMID: 33844597
- Affinity of benzoquinonium and ambenonium derivatives for the acetylcholine receptor, tested on the electroplax, and for acetylcholinesterase in solution. | Webb, GD. 1965. Biochim Biophys Acta. 102: 172-84. PMID: 5833399
Inhibitor of:
AChE.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ambenonium dichloride, 10 mg | sc-203507 | 10 mg | $123.00 | |||
Ambenonium dichloride, 50 mg | sc-203507A | 50 mg | $530.00 |