Ambenonium dichloride CAS: 52022-31-8
MF: C28H42Cl2N4O2•Cl2
MW: 608.48
A selective, potent and rapid reversible inhibitor of AChE.

Ambenonium dichloride (CAS 52022-31-8)

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Alternate Names: N,N'-[(1,2-Dioxo-1,2-ethanediyl)bis( imino-2,1-ethanediyl)]bis(2-chloro-N,N-diethylbenz enemethaminium) dichloride
Application: Ambenonium dichloride is a selective, potent and rapid reversible inhibitor of AChE
CAS Number: 52022-31-8
Molecular Weight: 608.48
Molecular Formula: C28H42Cl2N4O2•Cl2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Ambenonium dichloride is the dichloride salt of Ambenonium, a selective inhibitor of acetylcholine esterase (AChE). Ambenonium is described to be a rapidly reversible noncovalent inhibitor of AChE, demonstrating high affinity (IC50 = 0.698 nM) at AChE and a lower affinity (IC50 = 8.20 μM) at BChE (butyrylcholine esterase).


References

1. Webb, G.D. 1965. Biochim. Biophys. Acta. 102: 172-184. PMID: 5833399
2. Hodge, A.S., et al. 1992. Mol. Pharmacol. 41: 937-942. PMID: 1588924
3. Bolognesi, M.L., et al. 2003. Farmaco. 58: 917-928. PMID: 13679187
4. Musilek, K., et al. 2010. Eur J Med Chem. [Epub ahead of print]. PMID: 21236521

Physical State :
Solid
Solubility :
Soluble in water (100 mM).
Storage :
Store at room temperature
Melting Point :
196-199° C (Predicted)
IC50 :
AChE: IC50 = 0.698 nM; BChE: IC50 = 8200 nM
pK Values :
pKa: 11.09 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
8288
MDL Number :
MFCD00153762
EC Number :
204-107-5
SMILES :
CC[N+](CC)(CCNC(=O)C(=O)NCC[N+](CC)(CC)CC1=CC=CC=C1Cl)CC2=CC=CC=C2Cl.[Cl-].[Cl-]

Download SDS (MSDS)

Certificate of Analysis

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