Ambenonium dichloride is the dichloride salt of Ambenonium, a selective inhibitor of acetylcholine esterase (AChE). Ambenonium is described to be a rapidly reversible noncovalent inhibitor of AChE, demonstrating high affinity (IC50 = 0.698 nM) at AChE and a lower affinity (IC50 = 8.20 μM) at BChE (butyrylcholine esterase).
1. Webb, G.D. 1965. Biochim. Biophys. Acta. 102: 172-184. PMID: 5833399 2. Hodge, A.S., et al. 1992. Mol. Pharmacol. 41: 937-942. PMID: 1588924 3. Bolognesi, M.L., et al. 2003. Farmaco. 58: 917-928. PMID: 13679187 4. Musilek, K., et al. 2010. Eur J Med Chem. [Epub ahead of print]. PMID: 21236521
Soluble in water (100 mM).
Store at room temperature
196-199° C (Predicted)
AChE: IC50 = 0.698 nM; BChE: IC50 = 8200 nM
pKa: 11.09 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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