Molecular structure of ALX-1393, CAS Number: 949164-09-4
ALX-1393 (CAS 949164-09-4)
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Alternate Names:
O-[(2-Benzyloxyphenyl-3-flurophenyl)methyl]-L-serine
CAS Number:
949164-09-4
Purity:
>98%
Molecular Weight:
395.42
Molecular Formula:
C23H22NO4F
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
ALX-1393 is an inhibitor of the glycine transporter GlyT2. ALX-1393 is recognized for its selective antagonistic effects on the glycine site of the N-methyl-D-aspartate (NMDA) receptor. The NMDA receptor is a critical ion channel in the central nervous system that plays a pivotal role in synaptic transmission and plasticity. Glycine, a co-agonist along with glutamate for the NMDA receptor, binds to a specific site that is necessary for the receptor′s activation. By inhibiting this site, ALX-1393 modulates the receptor′s activity.
ALX-1393 (CAS 949164-09-4) References
- Inhibitors of GlyT1 and GlyT2 differentially modulate inhibitory transmission. | Xu, TX., et al. 2005. Neuroreport. 16: 1227-31. PMID: 16012354
- Mechanisms of [(3)H]glycine release from mouse spinal cord synaptosomes selectively labeled through GLYT2 transporters. | Luccini, E. and Raiteri, L. 2007. J Neurochem. 103: 2439-48. PMID: 17944872
- Differential effects of spinally applied glycine transporter inhibitors on nociception in a rat model of neuropathic pain. | Hermanns, H., et al. 2008. Neurosci Lett. 445: 214-9. PMID: 18793697
- N-arachidonyl-glycine modulates synaptic transmission in superficial dorsal horn. | Jeong, HJ., et al. 2010. Br J Pharmacol. 161: 925-35. PMID: 20860669
- Glycine receptors influence radial migration in the embryonic mouse neocortex. | Nimmervoll, B., et al. 2011. Neuroreport. 22: 509-13. PMID: 21666516
- Glycine transporter type 2 (GlyT2) inhibitor ameliorates bladder overactivity and nociceptive behavior in rats. | Yoshikawa, S., et al. 2012. Eur Urol. 62: 704-12. PMID: 22341128
- GlyT1 and GlyT2 in brain astrocytes: expression, distribution and function. | Aroeira, RI., et al. 2014. Brain Struct Funct. 219: 817-30. PMID: 23529192
- Glycine transporter 1 modulates GABA release from amacrine cells by controlling occupancy of coagonist binding site of NMDA receptors. | Rozsa, E. and Vigh, J. 2013. J Neurophysiol. 110: 1393-403. PMID: 23803324
- Reversible inhibition of the glycine transporter GlyT2 circumvents acute toxicity while preserving efficacy in the treatment of pain. | Mingorance-Le Meur, A., et al. 2013. Br J Pharmacol. 170: 1053-63. PMID: 23962079
- ALX 1393 inhibits spontaneous network activity by inducing glycinergic tonic currents in the spinal ventral horn. | Eckle, VS. and Antkowiak, B. 2013. Neuroscience. 253: 165-71. PMID: 23994185
- Activation of glycine receptors modulates spontaneous epileptiform activity in the immature rat hippocampus. | Chen, R., et al. 2014. J Physiol. 592: 2153-68. PMID: 24665103
- Relief of cancer pain by glycine transporter inhibitors. | Motoyama, N., et al. 2014. Anesth Analg. 119: 988-995. PMID: 25076101
- Glycine transporters GlyT1 and GlyT2 are differentially modulated by glycogen synthase kinase 3β. | Jiménez, E., et al. 2015. Neuropharmacology. 89: 245-54. PMID: 25301276
- Electrophysiological evidence of increased glycine receptor-mediated phasic and tonic inhibition by blockade of glycine transporters in spinal superficial dorsal horn neurons of adult mice. | Oyama, M., et al. 2017. J Pharmacol Sci. 133: 162-167. PMID: 28302446
- Analysis of Binding Determinants for Different Classes of Competitive and Noncompetitive Inhibitors of Glycine Transporters. | Łątka, K. and Bajda, M. 2022. Int J Mol Sci. 23: PMID: 35887394
Inhibitor of:
GlyT2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ALX-1393, 500 µg | sc-300191 | 500 µg | $120.00 | |||
ALX-1393, 1 mg | sc-300191A | 1 mg | $180.00 |