Alsin Antibody (2J10): sc-134256

Alsin Antibody (2J10) is a mouse monoclonal IgG1 kappa light chain antibody that detects the Alsin protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Alsin antibody (2J10) is available as the non-conjugated form. Alsin, encoded by the ALS2 gene, plays a crucial role as a guanine nucleotide exchange factor for Rab5, which is essential for regulating the endocytic pathway. This function is particularly important as it facilitates the internalization of various molecules into the cell, thereby influencing cellular uptake and signaling processes. Mutations in the ALS2 gene are linked to several juvenile recessive motor neuron diseases, including juvenile primary lateral sclerosis, infantile onset ascending hereditary spastic paralysis, and a form of complicated hereditary spastic paraplegia. Alsin is predominantly located in the cytosol and is associated with small, punctate membrane structures, suggesting involvement in membrane transport events and the remodeling of the actin cytoskeleton. Additionally, the ALS2 C-terminal-like protein (ALS2CL) has been identified as a modulator of Rab5 activity, further underscoring the significance of Alsin in cellular dynamics.

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Alsin Antibody (2J10) References:

1. The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis.  |  Yang, Y., et al. 2001. Nat Genet. 29: 160-5. PMID: 11586297
2. Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor.  |  Topp, JD., et al. 2004. J Biol Chem. 279: 24612-23. PMID: 15033976
3. ALS2CL, the novel protein highly homologous to the carboxy-terminal half of ALS2, binds to Rab5 and modulates endosome dynamics.  |  Hadano, S., et al. 2004. FEBS Lett. 575: 64-70. PMID: 15388334
4. Cross-species characterization of the ALS2 gene and analysis of its pattern of expression in development and adulthood.  |  Devon, RS., et al. 2005. Neurobiol Dis. 18: 243-57. PMID: 15686953
5. The first ALS2 missense mutation associated with JPLS reveals new aspects of alsin biological function.  |  Panzeri, C., et al. 2006. Brain. 129: 1710-9. PMID: 16670179
6. Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities.  |  Devon, RS., et al. 2006. Proc Natl Acad Sci U S A. 103: 9595-600. PMID: 16769894
7. Alsin/Rac1 signaling controls survival and growth of spinal motoneurons.  |  Jacquier, A., et al. 2006. Ann Neurol. 60: 105-17. PMID: 16802292
8. Anti-ALS activity of alsin, the product of the ALS2 gene, and activity-dependent neurotrophic factor.  |  Matsuoka, M. and Nishimoto, I. 2005. Neurodegener Dis. 2: 135-8. PMID: 16909018

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Alsin Antibody (2J10) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Alsin Antibody (2J10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Alsin Antibody (2J10) Specifications

Alternate Product Name: Alsin

Product Clone Name: 2J10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 221-321

Epitope Target: Alsin

Epitope Species: human

Product Reactivity/Detection: Alsin

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Alsin Antibody (2J10): N/A