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SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
ALPPL2 Antibody (9-YD35) is a high quality monoclonal ALPPL2 antibody (also designated ALPG antibody, ALPPL antibody, or GCAP antibody) suitable for the detection of the ALPPL2 protein of human origin. ALPPL2 Antibody (9-YD35) is available as the non-conjugated anti-ALPPL2 antibody. ALPPL2 (alkaline phosphatase, placental-like 2), also known as ALPG, GCAP or ALPPL, is a 532 amino acid protein that is lipid-anchored to the cell membrane and belongs to the alkaline phosphatase family. Expressed at low levels in thymus and testis, ALPPL2 functions as a homodimer that uses magnesium and zinc as cofactors to catalyze the conversion of a phosphate monoester to an alcohol and a free phosphate. ALPPL2 is overexpressed in germ cell tumors, suggesting a role in tumor development and progression. The gene encoding ALPPL2 maps to human chromosome 2, which houses over 1,400 genes and comprises nearly 8% of the human genome. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene, while the lipid metabolic disorder sitosterolemia is associated with defects in the ABCG5 and ABCG8 genes. Additionally, an extremely rare recessive genetic disorder, Alström syndrome, is caused by mutations in the ALMS1 gene, which maps to chromosome 2.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Has this antibody been tested/validated for detection of cell surface expression in flow cytometry?
Asked by: scien
Thank you for your question. ALPPL2 Antibody (9-YD35): sc-134255 is only recommended for detection of ALPPL2 of human origin by WB, IP, IF, IHC(P) and ELISA.
Answered by: Tech Support Europe
Date published: 2021-02-09
Can sc-134255: ALPPL2 (9-YD35) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?
Asked by: jerojero
Thank you for your question. Yes, sc-134255: ALPPL2 (9-YD35) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here:
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