αC-crystallin Antibody (2H5): sc-51745

αC-crystallin Antibody (2H5) is a mouse monoclonal IgG2a light chain antibody that detects αC-crystallin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). αC-crystallin is a crucial member of the small heat shock protein family, specifically known for its role in maintaining lens transparency and refractive index in the vertebrate eye. Anti-αC-crystallin antibody (2H5) functions as a molecular chaperone, preventing the aggregation of denatured proteins. Notably, αC-crystallin is composed of three gene products—αA, αB, and αC—and features a complex structure that includes seven distinctive protein regions, which contribute to chaperone activity. αC-crystallin′s ability to bind to membranes, particularly at the polar-apolar interface with membrane proteins like MIP26, is significant as this interaction influences the mobility of the lipid bilayer, thereby playing a vital role in cellular stability and function. αC-crystallin monoclonal antibody (2H5) serves as an invaluable tool for researchers studying the molecular mechanisms underlying lens transparency and the protective roles of crystallins in various stress conditions.

The preferred αC-crystallin antibody is αC-crystallin Antibody (H-5): sc-398395.