αB-crystallin Antibody (C-5): sc-398079

αB-crystallin Antibody (C-5) is a mouse monoclonal IgG2a antibody that detects αB-crystallin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). αB-crystallin is a member of the small heat shock protein family and plays a crucial role in cellular stress response by acting as a molecular chaperone, preventing the aggregation of denatured proteins and maintaining cellular protein homeostasis. This function is particularly important in tissues that are subject to high levels of stress, such as the heart and skeletal muscle, where elevated expression of αB-crystallin has been linked to various neurological diseases. Notably, a missense mutation in the αB-crystallin gene has been associated with Desmin-related myopathy, highlighting its significance in muscle integrity and function. The unique structure of αB-crystallin, which includes a conserved α-crystallin domain, allows αB-crystallin to interact with a variety of client proteins, thereby influencing their stability and activity. Anti-αB-crystallin antibody (C-5) is an essential tool for researchers studying the role of αB-crystallin in health and disease, providing insights into its involvement in cellular protection mechanisms and potential therapeutic targets.

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αB-crystallin Antibody (C-5) References:

1. Binding of the stress protein alpha B-crystallin to cardiac myofibrils correlates with the degree of myocardial damage during ischemia/reperfusion in vivo.  |  Golenhofen, N., et al. 1999. J Mol Cell Cardiol. 31: 569-80. PMID: 10198188
2. Mutation of COOH-terminal lysines in overexpressed alpha B-crystallin abrogates ischemic protection in cardiomyocytes.  |  Martin, JL., et al. 2002. Am J Physiol Heart Circ Physiol. 283: H85-91. PMID: 12063278
3. Alpha B-crystallin suppresses pressure overload cardiac hypertrophy.  |  Kumarapeli, AR., et al. 2008. Circ Res. 103: 1473-82. PMID: 18974385
4. Expression of alpha B-crystallin in the developing rat kidney.  |  Iwaki, T., et al. 1991. Kidney Int. 40: 52-6. PMID: 1921155
5. Alpha-B-crystallin induces an immune-regulatory and antiviral microglial response in preactive multiple sclerosis lesions.  |  Bsibsi, M., et al. 2013. J Neuropathol Exp Neurol. 72: 970-9. PMID: 24042199
6. Alpha B-crystallin prevents ventricular arrhythmia by attenuating inflammation and oxidative stress in rat with autoimmune myocarditis.  |  Park, H., et al. 2015. Int J Cardiol. 182: 399-402. PMID: 25596465
7. Alpha B crystallin and HSP28 are enhanced in the cerebral cortex of patients with Alzheimer's disease.  |  Shinohara, H., et al. 1993. J Neurol Sci. 119: 203-8. PMID: 8277336
8. Age-dependent deamidation of alpha B-crystallin.  |  Groenen, PJ., et al. 1993. FEBS Lett. 322: 69-72. PMID: 8482371
9. Chaperone activity of alpha B-crystallin suppresses tubulin aggregation through complex formation.  |  Arai, H. and Atomi, Y. 1997. Cell Struct Funct. 22: 539-44. PMID: 9431459
10. Evidence for the participation of alpha B-crystallin in human age-related nuclear cataract.  |  Truscott, RJ., et al. 1998. Int J Biol Macromol. 22: 321-30. PMID: 9650087

The preferred αB-crystallin antibody is αB-crystallin Antibody (F-10): sc-137129.