α4a Tubulin Antibody (MH-17): sc-134241

α4a Tubulin Antibody (MH-17) is a mouse monoclonal IgG2a kappa light chain antibody that detects alpha 4a Tubulin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-alpha 4a Tubulin antibody (MH-17) is available as a non-conjugated format. Tubulin plays a crucial role in maintaining cell shape, enabling intracellular transport, and facilitating cell division, making alpha 4a Tubulin essential for proper cellular function and organization. Alpha and beta Tubulin heterodimers assemble into microtubules, which are dynamic structures that can rapidly grow and shrink, allowing cells to adapt to various physiological conditions. Regulation of microtubule dynamics is vital for processes such as mitosis, where microtubules form the mitotic spindle to segregate chromosomes, and for intracellular transport, where motor proteins travel along microtubules to deliver cellular cargo. Understanding alpha 4a Tubulin function and interactions with other proteins is important for elucidating mechanisms underlying cellular processes and potential implications in diseases where cytoskeletal dynamics are disrupted.

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α4a Tubulin Antibody (MH-17) References:

1. Presence of the betaII isotype of tubulin in the nuclei of cultured mesangial cells from rat kidney.  |  Walss, C., et al. 1999. Cell Motil Cytoskeleton. 42: 274-84. PMID: 10223634
2. Identification of betaIII- and betaIV-tubulin isotypes in cold-adapted microtubules from Atlantic cod (Gadus morhua): antibody mapping and cDNA sequencing.  |  Modig, C., et al. 1999. Cell Motil Cytoskeleton. 42: 315-30. PMID: 10223637
3. Delta-tubulin and epsilon-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function.  |  Chang, P. and Stearns, T. 2000. Nat Cell Biol. 2: 30-5. PMID: 10620804
4. Tubulin immunoreactive neuronal intranuclear inclusions in the human brain.  |  Woulfe, J. and Munoz, D. 2000. Neuropathol Appl Neurobiol. 26: 161-71. PMID: 10840279
5. Alpha-, beta-, and gamma-tubulins: sequence comparisons and structural constraints.  |  Burns, RG. 1991. Cell Motil Cytoskeleton. 20: 181-9. PMID: 1773446
6. Gamma-tubulin is present in Drosophila melanogaster and Homo sapiens and is associated with the centrosome.  |  Zheng, Y., et al. 1991. Cell. 65: 817-23. PMID: 1904010
7. Invited review: the role of nucleotide triphosphate in actin and tubulin assembly and function.  |  Weisenberg, RC. 1981. Cell Motil. 1: 485-97. PMID: 6756643
8. Multiple forms of tubulin: different gene products and covalent modifications.  |  Ludueña, RF. 1998. Int Rev Cytol. 178: 207-75. PMID: 9348671
9. Expression of amino- and carboxyl-terminal gamma- and alpha-tubulin mutants in cultured epithelial cells.  |  Leask, A. and Stearns, T. 1998. J Biol Chem. 273: 2661-8. PMID: 9446570

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-α4a Tubulin Antibody (MH-17) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-α4a Tubulin Antibody (MH-17) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

α4a Tubulin Antibody (MH-17) Specifications

Alternate Product Name: tubulin alpha 4a

Product Clone Name: MH-17

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-449

Epitope Target: α4a Tubulin

Epitope Species: human

Product Reactivity/Detection: α4a Tubulin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for α4a Tubulin Antibody (MH-17): N/A