α3 Tubulin Antibody (10J1): sc-134240

α3 Tubulin Antibody (10J1) is a mouse monoclonal IgG1 kappa light chain antibody that detects alpha 3 Tubulin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-alpha 3 Tubulin antibody (10J1) is available as the non-conjugated format. Tubulin, a crucial component of the cytoskeleton, plays a vital role in maintaining cell shape, enabling intracellular transport, and facilitating cell division. The protein exists in five distinct forms, including alpha, beta, gamma, delta, and epsilon Tubulin, with alpha and beta Tubulins forming heterodimers that polymerize to create microtubule filaments essential for various cellular functions. Notably, alpha 3 Tubulin′s interaction with other tubulin isoforms, particularly beta Tubulin, is critical for the dynamic stability of microtubules, which are involved in processes such as mitosis and intracellular transport. Proper functioning of microtubules is essential for cellular integrity and organization, making alpha 3 Tubulin and its interactions significant for understanding various biological processes and potential disease mechanisms.

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α3 Tubulin Antibody (10J1) References:

1. Presence of the betaII isotype of tubulin in the nuclei of cultured mesangial cells from rat kidney.  |  Walss, C., et al. 1999. Cell Motil Cytoskeleton. 42: 274-84. PMID: 10223634
2. Identification of betaIII- and betaIV-tubulin isotypes in cold-adapted microtubules from Atlantic cod (Gadus morhua): antibody mapping and cDNA sequencing.  |  Modig, C., et al. 1999. Cell Motil Cytoskeleton. 42: 315-30. PMID: 10223637
3. Delta-tubulin and epsilon-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function.  |  Chang, P. and Stearns, T. 2000. Nat Cell Biol. 2: 30-5. PMID: 10620804
4. Tubulin immunoreactive neuronal intranuclear inclusions in the human brain.  |  Woulfe, J. and Munoz, D. 2000. Neuropathol Appl Neurobiol. 26: 161-71. PMID: 10840279
5. Alpha-, beta-, and gamma-tubulins: sequence comparisons and structural constraints.  |  Burns, RG. 1991. Cell Motil Cytoskeleton. 20: 181-9. PMID: 1773446
6. Gamma-tubulin is present in Drosophila melanogaster and Homo sapiens and is associated with the centrosome.  |  Zheng, Y., et al. 1991. Cell. 65: 817-23. PMID: 1904010
7. Invited review: the role of nucleotide triphosphate in actin and tubulin assembly and function.  |  Weisenberg, RC. 1981. Cell Motil. 1: 485-97. PMID: 6756643
8. Multiple forms of tubulin: different gene products and covalent modifications.  |  Ludueña, RF. 1998. Int Rev Cytol. 178: 207-75. PMID: 9348671
9. Expression of amino- and carboxyl-terminal gamma- and alpha-tubulin mutants in cultured epithelial cells.  |  Leask, A. and Stearns, T. 1998. J Biol Chem. 273: 2661-8. PMID: 9446570

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-α3 Tubulin Antibody (10J1) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-α3 Tubulin Antibody (10J1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

α3 Tubulin Antibody (10J1) Specifications

Alternate Product Name: tubulin alpha 3c

Product Clone Name: 10J1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-419

Epitope Target: α3C Tubulin

Epitope Species: human

Product Reactivity/Detection: α3 Tubulin and α1 Tubulin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for α3 Tubulin Antibody (10J1): N/A