α2B-AR Antibody (C-4): sc-390429
- α2B-AR Antibody (C-4) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against amino acids 202-297 of α2B-AR of human origin
- recommended for detection of α2B-AR of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG2a BP-HRP is the preferred secondary detection reagent for α2B-AR Antibody (C-4) for WB applications. This reagent is now offered in a bundle with α2B-AR Antibody (C-4) (see ordering information below).
α2B-AR Antibody (C-4) is a mouse monoclonal IgG2a antibody that detects α2B-adrenergic receptor (α2B-AR) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). α2B-AR is a member of the G protein-coupled receptor superfamily and plays a pivotal role in the regulation of neurotransmitter release from sympathetic nerves and adrenergic neurons in the central nervous system. α2B-AR′s structure consists of seven transmembrane domains that facilitate interaction with G proteins, allowing mediation of various physiological responses, including vasoconstriction and modulation of blood pressure. α2B-AR can couple with Gi-proteins, which are crucial for inducing salt-dependent hypertension in response to catecholamines. The carboxy-terminal cytoplasmic domain of α2B-AR associates with several proteins, including the guanine nucleotide exchange factor eIF-2B, highlighting α2B-AR′s role in intracellular signaling pathways. The abundance of α2B-AR transcripts in rat liver and kidney further underscores α2B-AR′s significance in physiological processes, making anti-α2B-AR antibody (C-4) an essential tool for researchers studying adrenergic signaling and its implications in health and disease.
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α2B-AR Antibody (C-4) References:
- Deletion polymorphism in the alpha2B-adrenergic receptor gene is associated with flow-mediated dilatation of the brachial artery. | Heinonen, P., et al. 2002. Clin Sci (Lond). 103: 517-24. PMID: 12401126
- Central alpha2B-adrenergic receptor antisense in plasmid vector prolongs reversal of salt-dependent hypertension. | Kintsurashvili, E., et al. 2003. J Hypertens. 21: 961-7. PMID: 12714871
- Alpha2B adrenergic receptor 301-303 deletion polymorphism and vascular alpha2 adrenergic receptor response. | Muszkat, M., et al. 2005. Pharmacogenet Genomics. 15: 23-8. PMID: 15864122
- Alpha2B-adrenergic receptor interaction with tubulin controls its transport from the endoplasmic reticulum to the cell surface. | Duvernay, MT., et al. 2011. J Biol Chem. 286: 14080-9. PMID: 21357695
- The α2B-adrenergic receptor is mutant in cortical myoclonus and epilepsy. | De Fusco, M., et al. 2014. Ann Neurol. 75: 77-87. PMID: 24114805
- Relationship between human evolution and neurally mediated syncope disclosed by the polymorphic sites of the adrenergic receptor gene α2B-AR. | Komiyama, T., et al. 2015. PLoS One. 10: e0120788. PMID: 25860977
- Spinophilin Is Indispensable for the α2B Adrenergic Receptor-Elicited Hypertensive Response. | Che, P., et al. 2015. PLoS One. 10: e0135030. PMID: 26244553
- Alpha2B-Adrenergic Receptor Overexpression in the Brain Potentiate Air Pollution-induced Behavior and Blood Pressure Changes. | Rao, X., et al. 2019. Toxicol Sci. 169: 95-107. PMID: 30812033
- Alpha2B-Adrenergic Receptor Regulates Neutrophil Recruitment in MSU-Induced Peritoneal Inflammation. | Duan, L., et al. 2019. Front Immunol. 10: 501. PMID: 30941135
- Role of the alpha2B-adrenergic receptor in the development of salt-induced hypertension. | Makaritsis, KP., et al. 1999. Hypertension. 33: 14-7. PMID: 9931075
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
α2B-AR Antibody (C-4) | sc-390429 | 200 µg/ml | $316.00 | |||
α2B-AR Antibody (C-4): m-IgG2a BP-HRP Bundle | sc-546072 | 200 µg Ab; 10 µg BP | $354.00 |