alpha Tubulin Antibody (3H3087): sc-69971

α Tubulin Antibody (3H3087) is a rat monoclonal IgG2a antibody that recognizes α Tubulin, a core protein of the cytoskeleton, from mouse, rat, human, and yeast sources. Raised against full-length, purified α Tubulin derived from Saccharomyces cerevisiae, anti-α Tubulin antibody (3H3087) is suitable for a variety of applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry (IHC), with particular utility for detecting the tyrosinated form of α Tubulin. α Tubulin, a critical component of microtubules, partners with β Tubulin to form heterodimers that polymerize into microtubules, which are essential for maintaining cell structure, intracellular transport, and chromosome segregation during mitosis. The dynamic instability of microtubules, regulated by post-translational modifications such as tyrosination and detyrosination of α Tubulin, is crucial for cell motility, neurogenesis, and ciliogenesis. α Tubulin interacts with several other proteins involved in microtubule dynamics, including motor proteins like kinesin and dynein, as well as microtubule-associated proteins (MAPs) that stabilize or promote disassembly. Known alternately as Tubulin alpha chain or TUBA1A, α Tubulin also plays a key role in the formation of cilia and flagella, structures essential for cellular signaling and movement. α Tubulin regulation, particularly the modification of tubulin subunits at the centrosome and during mitotic spindle formation, is vital for proper cell division and tissue homeostasis. α Tubulin (3H3087) monoclonal antibody is an important tool for studying microtubule dynamics, protein interactions, and the molecular mechanisms that regulate cellular structure and function.

The preferred alpha Tubulin antibody is alpha Tubulin Antibody (TU-02): sc-8035.