α-taxilin Antibody (E-2): sc-271783

α-taxilin Antibody (E-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects human α-taxilin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). α-taxilin Antibody (E-2) is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. α-taxilin (E-2) antibody targets a protein that plays a crucial role in intracellular vesicle trafficking as a novel binding partner of the syntaxin family, essential for proper transport and delivery of proteins within cells. α-taxilin′s C-terminal coiled-coil region facilitates interaction with the nascent polypeptide-associated complex (NAC), a key transcriptional coactivator influencing gene expression. α-taxilin (E-2) monoclonal antibody recognizes a protein that primarily interacts with the α subunit of NAC, and co-expression studies show that when α-taxilin is overexpressed alongside αNAC, disruption occurs in the nuclear distribution of αNAC, typically found throughout the cytosol and nucleus. This interaction highlights the dual role of the taxilin family, not only in the translational process through NAC binding but also in transcriptional regulation via specific interaction with αNAC. Understanding α-taxilin′s dynamics and interactions is vital for elucidating mechanisms of intracellular transport and gene regulation, making anti-α-taxilin antibody (E-2) an invaluable research tool for studying these processes.

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α-taxilin Antibody (E-2) References:

1. Taxilin; a novel syntaxin-binding protein that is involved in Ca2+-dependent exocytosis in neuroendocrine cells.  |  Nogami, S., et al. 2003. Genes Cells. 8: 17-28. PMID: 12558796
2. Interaction of taxilin with syntaxin which does not form the SNARE complex.  |  Nogami, S., et al. 2003. Biochem Biophys Res Commun. 311: 797-802. PMID: 14623251
3. Identification and characterization of taxilin isoforms.  |  Nogami, S., et al. 2004. Biochem Biophys Res Commun. 319: 936-43. PMID: 15184072
4. Interaction of the taxilin family with the nascent polypeptide-associated complex that is involved in the transcriptional and translational processes.  |  Yoshida, K., et al. 2005. Genes Cells. 10: 465-76. PMID: 15836775
5. Estrogen modulation of hypothalamic neurons: activation of multiple signaling pathways and gene expression changes.  |  Malyala, A., et al. 2005. Steroids. 70: 397-406. PMID: 15862823
6. Expression of α-taxilin in hepatocellular carcinoma correlates with growth activity and malignant potential of the tumor.  |  Ohtomo, N., et al. 2010. Int J Oncol. 37: 1417-23. PMID: 21042709
7. Increased alpha-taxilin protein expression is associated with the metastatic and invasive potential of renal cell cancer.  |  Mashidori, T., et al. 2011. Biomed Res. 32: 103-10. PMID: 21551945
8. Identification of α-taxilin as an essential factor for the life cycle of hepatitis B virus.  |  Hoffmann, J., et al. 2013. J Hepatol. 59: 934-41. PMID: 23816704
9. α-Taxilin interacts with sorting nexin 4 and participates in the recycling pathway of transferrin receptor.  |  Sakane, H., et al. 2014. PLoS One. 9: e93509. PMID: 24690921
10. Characterization of α-taxilin as a novel factor controlling the release of hepatitis C virus.  |  Elgner, F., et al. 2016. Biochem J. 473: 145-55. PMID: 26527738
11. TXLNA enhances TBK1 phosphorylation by suppressing PPM1B recruitment.  |  Tian, X., et al. 2023. Biochim Biophys Acta Mol Cell Res. 1870: 119550. PMID: 37506885
12. Expression of TXLNA in brain gliomas and its clinical significance: a bioinformatics analysis.  |  Hu, B., et al. 2023. Chin Neurosurg J. 9: 27. PMID: 37752559

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-α-taxilin Antibody (E-2) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-α-taxilin Antibody (E-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

α-taxilin Antibody (E-2) Specifications

Alternate Product Name: α-taxilin

Product Clone Name: E-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 481-546

Epitope Target: α-taxilin

Epitope Species: human

Product Reactivity/Detection: α-taxilin

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for α-taxilin Antibody (E-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin