α T-catenin Antibody (212): sc-81794

α T-catenin Antibody (212) is a mouse monoclonal IgG1 antibody that detects α T-catenin in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). α T-catenin, also known as VR22, is a crucial 895-amino acid protein predominantly expressed in cardiomyocytes and peritubular myoid cells of the testis, where anti-α T-catenin antibody (212) plays a vital role in cellular adhesion by forming complexes with E-cadherin at cellular junctions. These catenin/cadherin complexes are essential for maintaining tissue integrity and regulating cell signaling pathways, particularly in inhibiting Wnt signaling, which is critical for various developmental processes and cellular functions. The gene encoding α T-catenin, CTNNA3, is located on chromosome 10, and mutations in this gene have been linked to significant health issues, including late-onset Alzheimer′s disease and dilated cardiomyopathy, highlighting the importance of α T-catenin in both normal physiology and disease states. With insights into these critical biological processes, α T-catenin monoclonal antibody (212) serves as an invaluable tool for researchers studying cell adhesion mechanisms and their implications in human health.

The preferred α T-catenin antibody is α T-catenin Antibody (B-6): sc-398138.