α-Syntrophin Antibody (F-1): sc-166635

α-Syntrophin Antibody (F-1) is a mouse monoclonal IgG1 antibody that detects α-Syntrophin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). α-Syntrophin is a crucial member of the syntrophin family, which consists of PDZ-domain-containing proteins that play a significant role in the recruitment of signaling proteins, including nitric oxide synthase 1 (NOS1), to the dystrophin-associated protein complex. This interaction is vital for maintaining the integrity of the neuromuscular junction, where α-Syntrophin is primarily located at the muscle sarcolemma. α-Syntrophin′s ability to associate with dystrophin and its homologs is essential for synapse formation and the organization of key components such as utrophin and acetylcholine receptors at the neuromuscular synapse. Furthermore, α-Syntrophin′s structural features, including multiple protein interaction motifs, enable functioning as a modular adapter, facilitating interactions with other proteins that are critical for muscle function and signaling. Anti-α-Syntrophin antibody (F-1) helps researchers gain insights into the dynamics of these protein interactions and their implications in muscle physiology and related disorders.

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α-Syntrophin Antibody (F-1) References:

1. Absence of alpha-syntrophin leads to structurally aberrant neuromuscular synapses deficient in utrophin.  |  Adams, ME., et al. 2000. J Cell Biol. 150: 1385-98. PMID: 10995443
2. An alpha-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain.  |  Amiry-Moghaddam, M., et al. 2003. Proc Natl Acad Sci U S A. 100: 2106-11. PMID: 12578959
3. Vasomodulation by skeletal muscle-derived nitric oxide requires alpha-syntrophin-mediated sarcolemmal localization of neuronal Nitric oxide synthase.  |  Thomas, GD., et al. 2003. Circ Res. 92: 554-60. PMID: 12600881
4. Differential effect of alpha-syntrophin knockout on aquaporin-4 and Kir4.1 expression in retinal macroglial cells in mice.  |  Puwarawuttipanit, W., et al. 2006. Neuroscience. 137: 165-75. PMID: 16257493
5. The alpha-syntrophin PH and PDZ domains scaffold acetylcholine receptors, utrophin, and neuronal nitric oxide synthase at the neuromuscular junction.  |  Adams, ME., et al. 2010. J Neurosci. 30: 11004-10. PMID: 20720107
6. Nicotinic acetylcholine receptor stability at the NMJ deficient in α-syntrophin in vivo.  |  Martinez-Pena y Valenzuela, I., et al. 2011. J Neurosci. 31: 15586-96. PMID: 22031904
7. Regional registration of [6-(14)C]glucose metabolism during brain activation of α-syntrophin knockout mice.  |  Cruz, NF., et al. 2013. J Neurochem. 125: 247-59. PMID: 23346911
8. Nuclear recruitment of neuronal nitric-oxide synthase by α-syntrophin is crucial for the induction of mitochondrial biogenesis.  |  Aquilano, K., et al. 2014. J Biol Chem. 289: 365-78. PMID: 24235139
9. Alpha-syntrophin deficient mice are protected from adipocyte hypertrophy and ectopic triglyceride deposition in obesity.  |  Eisinger, K., et al. 2018. Exp Mol Pathol. 104: 212-221. PMID: 29702112
10. Alpha-syntrophin deficiency protects against non-alcoholic steatohepatitis associated increase of macrophages, CD8+ T-cells and galectin-3 in the liver.  |  Rein-Fischboeck, L., et al. 2020. Exp Mol Pathol. 113: 104363. PMID: 31881201

The preferred α-Syntrophin antibody is α-Syntrophin Antibody (D-7): sc-166634.