α-Syntrophin Antibody (C-7): sc-166207
- α-Syntrophin Antibody (C-7) is a mouse monoclonal IgG2b κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2-39 at the N-terminus of α-Syntrophin of human origin
- recommended for detection of α-Syntrophin of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG2b BP-HRP is the preferred secondary detection reagent for α-Syntrophin Antibody (C-7) for WB applications. This reagent is now offered in a bundle with α-Syntrophin Antibody (C-7) (see ordering information below).
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α-Syntrophin Antibody (C-7) is a mouse monoclonal IgG2b light chain antibody that detects α-Syntrophin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). α-Syntrophin plays a crucial role in the organization of the dystrophin-associated protein complex, which is essential for maintaining the integrity of muscle fibers and facilitating effective signaling at the neuromuscular junction. α-Syntrophin (C-7) antibody targets proteins primarily located at the sarcolemma of muscle cells, where α-Syntrophin interacts with dystrophin and other signaling proteins, including nitric oxide synthase 1 (NOS1). The localization of α-Syntrophin is vital because α-Syntrophin ensures the proper assembly of the dystrophin complex, which is necessary for muscle function and stability. Disruption of this complex can lead to severe muscle disorders, including Duchenne muscular dystrophy. Anti-α-Syntrophin antibody (C-7) helps researchers gain insights into the dynamics of muscle cell signaling and the pathophysiology of related diseases, making α-Syntrophin (C-7) monoclonal antibody an invaluable tool for both basic and translational research.
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α-Syntrophin Antibody (C-7) References:
- In vivo requirement of the alpha-syntrophin PDZ domain for the sarcolemmal localization of nNOS and aquaporin-4. | Adams, ME., et al. 2001. J Cell Biol. 155: 113-22. PMID: 11571312
- Assembly of a perivascular astrocyte protein scaffold at the mammalian blood-brain barrier is dependent on alpha-syntrophin. | Bragg, AD., et al. 2006. Glia. 53: 879-90. PMID: 16609960
- Aberrantly spliced alpha-dystrobrevin alters alpha-syntrophin binding in myotonic dystrophy type 1. | Nakamori, M., et al. 2008. Neurology. 70: 677-85. PMID: 18299519
- Α-syntrophin modulates myogenin expression in differentiating myoblasts. | Kim, MJ., et al. 2010. PLoS One. 5: e15355. PMID: 21179410
- α-Syntrophin is required for the hepatocyte growth factor-induced migration of cultured myoblasts. | Kim, MJ., et al. 2011. Exp Cell Res. 317: 2914-24. PMID: 22001117
- Altered astrocytic swelling in the cortex of α-syntrophin-negative GFAP/EGFP mice. | Anderova, M., et al. 2014. PLoS One. 9: e113444. PMID: 25426721
- α-Syntrophin is involved in the survival signaling pathway in myoblasts under menadione-induced oxidative stress. | Lim, JA., et al. 2016. Exp Cell Res. 344: 1-10. PMID: 27086165
- α-Syntrophin stabilizes catalase to reduce endogenous reactive oxygen species levels during myoblast differentiation. | Moon, JY., et al. 2017. FEBS J. 284: 2052-2065. PMID: 28485891
- α-Syntrophin alleviates ER stress to maintain protein homeostasis during myoblast differentiation. | Moon, JY. and Kim, HS. 2021. FEBS Lett. 595: 1656-1670. PMID: 33834492
- Identification of alpha-syntrophin binding to syntrophin triplet, dystrophin, and utrophin. | Yang, B., et al. 1995. J Biol Chem. 270: 4975-8. PMID: 7890602
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
α-Syntrophin Antibody (C-7) | sc-166207 | 200 µg/ml | $322.00 | |||
α-Syntrophin Antibody (C-7): m-IgG2b BP-HRP Bundle | sc-548513 | 200 µg Ab; 10 µg BP | $361.00 | |||
α-Syntrophin (C-7) Neutralizing Peptide | sc-166207 P | 100 µg/0.5 ml | $69.00 |