α-sarcoglycan Antibody (F-7): sc-390647

α-sarcoglycan Antibody (F-7) is a mouse monoclonal IgG2a antibody that detects α-sarcoglycan in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). α-sarcoglycan Antibody (F-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. α-sarcoglycan plays a crucial role in the dystrophin-glycoprotein complex, which is essential for maintaining the structural integrity of muscle cell membranes. α-sarcoglycan is primarily located in the cell membrane of skeletal, cardiac, and smooth muscle fibers, where α-sarcoglycan forms a complex with other sarcoglycan subunits—β-, γ-, and δ-sarcoglycan. Proper functioning of this complex is vital, as mutations or deficiencies in any of these proteins can lead to severe muscle disorders, such as sarcoglycanopathy, an autosomal recessive muscular dystrophy characterized by muscle weakness and degeneration. In smooth muscle, β- and δ-sarcoglycans interact with ε-sarcoglycan, a glycoprotein that shares homology with α-sarcoglycan, highlighting the interconnectedness of these proteins in muscle function. A complete deficiency in δ-sarcoglycan has been linked to the development of cardiomyopathy in the Syrian hamster model, underscoring the importance of these proteins in both skeletal and cardiac muscle health.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-α-sarcoglycan Antibody (F-7) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-α-sarcoglycan Antibody (F-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

α-sarcoglycan Antibody (F-7) Specifications

Alternate Product Name: α-sarcoglycan

Product Clone Name: F-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a lambda light chain

Amino Acids: 43-68

Epitope Target: α-sarcoglycan

Epitope Species: human

Product Reactivity/Detection: α-sarcoglycan

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a lambda light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for α-sarcoglycan Antibody (F-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred α-sarcoglycan antibody is α-sarcoglycan Antibody (D-7): sc-271321.