MF: C6H11N3•2HBr MW: 287 A less active enantiomer of H3 agonist R-(−)-α-methylhistamine.
Protein-Interacting Inhibitors, Activators & Substrates
Histamine H3 Receptor Activators
(+)-α-Methylhistamine dihydrobromide (CAS 75614-93-6)
C 6H 11N 3• 2HBr
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use. *
Certificate of Analysis for lot specific data (including water content).
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(+)-α-Methylhistamine dihydrobromide is the less active enantiomer of histamine H3 receptor agonist R-(-)-α-methylhistamine. 120-fold less potent than R-(-) at H3.
Hill (1990) Distribution, properties and functional characteristics of three classes of histamine receptor. Pharmacol.Rev. 42 45.
Soluble in water (100 mM ).
Desiccate at room temperature
20 D 1.55 (Predicted)
α20/D +3°, c = 1 in water; α25/D +4°, c = 0.8 in water
Histamine H3 receptor: EC
5050 = 10 nM (human); Histamine H4 receptor: EC 5050 = 12.59 µM (human)
Histamine H3 receptor: K
i= 50 nM; Histamine H3 receptor: K i= 63.1 nM (human); Histamine H4 receptor: K i= 3.98 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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