α-lactalbumin Antibody (H-1): sc-393900
- α-lactalbumin Antibody (H-1) is a mouse monoclonal IgG2b κ α-lactalbumin antibody provided at 200 µg/ml
- raised against amino acids 1-142 representing full length α-lactalbumin of human origin
- alpha-lactalbumin Antibody (H-1) is recommended for detection of α-lactalbumin of human origin by WB, IP, IF and ELISA
- Anti-alpha-lactalbumin Antibody (H-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP is the preferred secondary detection reagent for α-lactalbumin Antibody (H-1) for WB applications. This reagent is now offered in a bundle with α-lactalbumin Antibody (H-1) (see ordering information below).
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α-lactalbumin Antibody (H-1) is a mouse monoclonal IgG2b kappa light chain antibody that detects alpha-lactalbumin protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). α-lactalbumin (H-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Alpha-lactalbumin plays a crucial role in lactose synthesis as a component of lactose synthetase, secreted by mammary epithelial cells. Alpha-lactalbumin facilitates lactose production, essential for infant nutrition, and exhibits significant biological activities, including calcium level elevation and apoptosis induction in certain cell types. Multimeric forms of alpha-lactalbumin have demonstrated selective cytotoxicity against transformed, embryonic, and lymphoid cells while sparing mature epithelial cells, indicating potential roles in immune regulation and mucosal immunity maintenance. Alpha-lactalbumin in milk may contribute to immune defense mechanisms in neonates, providing antimicrobial properties and lymphocyte function modulation. Human alpha-lactalbumin consists of 123 amino acids, with gene regulation influenced by conserved sequences in the 5′ flanking region, potentially playing a role in hormonal control and tissue-specific expression of milk proteins in the mammary gland.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
α-lactalbumin Antibody (H-1) References:
- High pressure-induced changes in bovine milk proteins: a review. | Huppertz, T., et al. 2006. Biochim Biophys Acta. 1764: 593-8. PMID: 16410058
- Food-protein enzymatic hydrolysates possess both antimicrobial and immunostimulatory activities: a 'cause and effect' theory of bifunctionality. | Biziulevicius, GA., et al. 2006. FEMS Immunol Med Microbiol. 46: 131-8. PMID: 16420606
- Molecular characterization of peptides released from beta-lactoglobulin and alpha-lactalbumin via cardosins A and B. | Barros, RM. and Malcata, FX. 2006. J Dairy Sci. 89: 483-94. PMID: 16428617
- Cadmium-induced disturbances in lactating mammary glands of mice. | Ohrvik, H., et al. 2006. Toxicol Lett. 164: 207-13. PMID: 16436318
- Protein instability during HIC: describing the effects of mobile phase conditions on instability and chromatographic retention. | Xiao, Y., et al. 2006. Biotechnol Bioeng. 93: 1177-89. PMID: 16444741
- Oleic acid inhibits amyloid formation of the intermediate of alpha-lactalbumin at moderately acidic pH. | Yang, F., et al. 2006. J Mol Biol. 362: 821-34. PMID: 16935298
- Quantitative assessment of thermal denaturation of bovine alpha-lactalbumin via low-intensity ultrasound, HPLC, and DSC. | Wang, Q., et al. 2006. J Agric Food Chem. 54: 6501-6. PMID: 16939303
- Effect of protein, nonprotein-soluble components, and lactose concentrations on the irreversible thermal denaturation of beta-lactoglobulin and alpha-lactalbumin in skim milk. | Anema, SG., et al. 2006. J Agric Food Chem. 54: 7339-48. PMID: 16968103
- Production and characterization of monoclonal antibodies to human casein. A monoclonal antibody that cross-reacts with casein and alpha-lactalbumin. | Burchell, J., et al. 1985. Hybridoma. 4: 341-50. PMID: 3905581
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
α-lactalbumin Antibody (H-1) | sc-393900 | 200 µg/ml | $322.00 | |||
α-lactalbumin Antibody (H-1): m-IgG2b BP-HRP Bundle | sc-548784 | 200 µg Ab; 10 µg BP | $361.00 | |||
α-lactalbumin Antibody (H-1) AC | sc-393900 AC | 500 µg/ml, 25% agarose | $424.00 | |||
α-lactalbumin Antibody (H-1) HRP | sc-393900 HRP | 200 µg/ml | $322.00 | |||
α-lactalbumin Antibody (H-1) FITC | sc-393900 FITC | 200 µg/ml | $336.00 | |||
α-lactalbumin Antibody (H-1) PE | sc-393900 PE | 200 µg/ml | $349.00 | |||
α-lactalbumin Antibody (H-1) Alexa Fluor® 488 | sc-393900 AF488 | 200 µg/ml | $364.00 | |||
α-lactalbumin Antibody (H-1) Alexa Fluor® 546 | sc-393900 AF546 | 200 µg/ml | $364.00 | |||
α-lactalbumin Antibody (H-1) Alexa Fluor® 594 | sc-393900 AF594 | 200 µg/ml | $364.00 | |||
α-lactalbumin Antibody (H-1) Alexa Fluor® 647 | sc-393900 AF647 | 200 µg/ml | $364.00 | |||
α-lactalbumin Antibody (H-1) Alexa Fluor® 680 | sc-393900 AF680 | 200 µg/ml | $364.00 | |||
α-lactalbumin Antibody (H-1) Alexa Fluor® 790 | sc-393900 AF790 | 200 µg/ml | $364.00 |