α-Dystrobrevin Antibody (F-6): sc-376782

α-Dystrobrevin Antibody (F-6) is a mouse monoclonal IgG1 antibody that detects α-Dystrobrevin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). α-Dystrobrevin is a crucial component of the dystrophin glycoprotein complex, which plays a significant role in maintaining muscle cell structural integrity. α-Dystrobrevin is primarily localized to the cytoplasmic side of the sarcolemma and concentrates at neuromuscular junctions in skeletal muscle, where α-Dystrobrevin is essential for synapse maturation and normal muscle function. Alternative splicing of α-Dystrobrevin results in several isoforms, including γ-Dystrobrevin, δ-Dystrobrevin, ε-Dystrobrevin, and ζ-Dystrobrevin, which may have distinct roles in different tissues. α-Dystrobrevin′s involvement in various muscular dystrophies, including Duchenne muscular dystrophy, can lead to severe muscle degeneration when disrupted. Through interactions with other proteins in the dystrophin complex, α-Dystrobrevin maintains proper functioning of muscle and neuronal tissues, making anti-α-Dystrobrevin antibody (F-6) an essential tool for researchers studying muscle-related diseases and cellular mechanisms.

The preferred Dystrobrevin antibody is Dystrobrevin Antibody (C-6): sc-271874.