α/β-SNAP Antibody (A-3): sc-271066
- α/β-SNAP Antibody (A-3) is a mouse monoclonal IgM κ provided at 200 µg/ml
- raised against a peptide mapping at the N-terminus of α-SNAP of human origin
- recommended for detection of α-SNAP and β-SNAP of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for α/β-SNAP Antibody (A-3). This work is in progress.
α/β-SNAP Antibody (A-3) is a mouse monoclonal IgM antibody that detects α/β-SNAP in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). α/β-SNAP plays a crucial role in the process of exocytosis, acting as a soluble NSF attachment protein that facilitates the binding of N-ethylmaleimide-sensitive factor (NSF) to the SNARE complex, which is essential for membrane fusion. This interaction is vital for the release of neurotransmitters and hormones, making α/β-SNAP integral to cellular communication and signaling. α/β-SNAP′s ability to mediate the assembly of the SNARE complex underscores its importance in various physiological processes, including synaptic transmission and secretion in neurons and endocrine cells. Using anti-α/β-SNAP antibody (A-3), researchers can gain insights into the mechanisms of exocytosis and its implications in neurobiology and other fields, enhancing our understanding of cellular dynamics and potential therapeutic targets.
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α/β-SNAP Antibody (A-3) References:
- Expression of neuroendocrine markers: a signature of human undifferentiated carcinoma of the colon and rectum. | Grabowski, P., et al. 2002. Virchows Arch. 441: 256-63. PMID: 12242522
- Heterogeneous expression of neuroendocrine marker proteins in human undifferentiated carcinoma of the colon and rectum. | Grabowski, P., et al. 2004. Ann N Y Acad Sci. 1014: 270-4. PMID: 15153444
- A ubiquitous membrane fusion protein alpha SNAP: a potential therapeutic target for cancer, diabetes and neurological disorders? | Andreeva, AV., et al. 2006. Expert Opin Ther Targets. 10: 723-33. PMID: 16981829
- α-SNAP inhibits AMPK signaling to reduce mitochondrial biogenesis and dephosphorylates Thr172 in AMPKα in vitro. | Wang, L. and Brautigan, DL. 2013. Nat Commun. 4: 1559. PMID: 23463002
- Store-operated calcium entry in disease: Beyond STIM/Orai expression levels. | Kappel, S., et al. 2019. Semin Cell Dev Biol. 94: 66-73. PMID: 30630032
- A Qa-SNARE complex contributes to soybean cyst nematode resistance via regulation of mitochondria-mediated cell death. | Wang, R., et al. 2021. J Exp Bot. 72: 7145-7162. PMID: 34165531
- High affinity associations with α-SNAP enable calcium entry via Orai1 channels. | Ramanagoudr-Bhojappa, R., et al. 2021. PLoS One. 16: e0258670. PMID: 34653219
- Munc18c accelerates SNARE-dependent membrane fusion in the presence of regulatory proteins α-SNAP and NSF. | Liu, F., et al. 2024. J Biol Chem. 300: 105782. PMID: 38395304
- A possible docking and fusion particle for synaptic transmission. | Schiavo, G., et al. 1995. Nature. 378: 733-6. PMID: 7501022
- Similar effects of alpha- and beta-SNAP on Ca(2+)-regulated exocytosis. | Sudlow, AW., et al. 1996. FEBS Lett. 393: 185-8. PMID: 8814286
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
α/β-SNAP Antibody (A-3) | sc-271066 | 200 µg/ml | $316.00 | |||
α/β-SNAP (A-3) Neutralizing Peptide | sc-271066 P | 100 µg/0.5 ml | $68.00 |