α-Adaptin 2 Antibody (A-8): sc-377376

α-Adaptin 2 Antibody (A-8) is a mouse monoclonal IgG2a antibody that detects α-Adaptin 2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). α-Adaptin 2 plays a crucial role in clathrin-mediated endocytosis, which is essential for receptor internalization and membrane protein regulation, thereby controlling cellular signaling and nutrient uptake. α-Adaptin 2 is primarily located at the plasma membrane and participates in forming clathrin-coated pits, which are vital for vesicle transport from cell surface to interior. Disruptions in α-Adaptin 2 function can lead to various diseases, including neurodegenerative disorders and cancer, where altered endocytic pathways affect cell signaling and proliferation. α-Adaptin 2 interacts with other proteins in the clathrin assembly machinery, such as γ-Adaptin and β-Adaptin, forming a complex essential for efficient clathrin recruitment and vesicle budding. anti-α-Adaptin 2 antibody (A-8) serves as an invaluable tool for researchers studying endocytic pathways and their implications in health and disease.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

α-Adaptin 2 Antibody (A-8) References:

1. Adaptor protein complex-2 (AP-2) and epsin-1 mediate protease-activated receptor-1 internalization via phosphorylation- and ubiquitination-dependent sorting signals.  |  Chen, B., et al. 2011. J Biol Chem. 286: 40760-70. PMID: 21965661
2. Asymmetric segregation and self-renewal of hematopoietic stem and progenitor cells with endocytic Ap2a2.  |  Ting, SB., et al. 2012. Blood. 119: 2510-22. PMID: 22174158
3. The role of Ap2a2 in PPARα-mediated regulation of lipolysis in adipose tissue.  |  Montgomery, MK., et al. 2019. FASEB J. 33: 13267-13279. PMID: 31533003
4. Suppression of µ1 subunit of the adaptor protein complex 2 reduces dengue virus release.  |  Tongmuang, N., et al. 2020. Virus Genes. 56: 27-36. PMID: 31720911
5. Alzheimer Disease Pathology-Associated Polymorphism in a Complex Variable Number of Tandem Repeat Region Within the MUC6 Gene, Near the AP2A2 Gene.  |  Katsumata, Y., et al. 2020. J Neuropathol Exp Neurol. 79: 3-21. PMID: 31748784
6. The MUC6/AP2A2 Locus and Its Relevance to Alzheimer's Disease: A Review.  |  Nelson, PT., et al. 2020. J Neuropathol Exp Neurol. 79: 568-584. PMID: 32357373
7. Defining the clinical, molecular and imaging spectrum of adaptor protein complex 4-associated hereditary spastic paraplegia.  |  Ebrahimi-Fakhari, D., et al. 2020. Brain. 143: 2929-2944. PMID: 32979048
8. Adaptor protein complex 2 in the orbitofrontal cortex predicts alcohol use disorder.  |  Mulholland, PJ., et al. 2023. Mol Psychiatry. 28: 4766-4776. PMID: 37679472
9. Exploring the Synergistic Mechanism of AP2A2 Transcription Factor Inhibition via Molecular Modeling and Simulations as a Novel Computational Approach for Combating Breast Cancer: In Silico Interpretations.  |  Niranjan, V., et al. 2024. Mol Biotechnol. 66: 2497-2521. PMID: 37747672
10. AP2A2 mutation and defective endocytosis in a Malian family with hereditary spastic paraplegia.  |  Diarra, S., et al. 2024. Neurobiol Dis. 198: 106537. PMID: 38772452

The preferred α-Adaptin 1/2 antibody is α-Adaptin 1/2 Antibody (C-8): sc-17771.