α-actinin-4 Antibody (D-3): sc-398088
- α-actinin-4 Antibody (D-3) is a mouse monoclonal mouse IgM κ κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 495-522 within an internal region of α-actinin-4 of human origin
- recommended for detection of α-actinin-4 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine, bovine and porcine
- m-IgGκ BP-HRP is the preferred secondary detection reagent for α-actinin-4 Antibody (D-3) for WB applications. This reagent is now offered in a bundle with α-actinin-4 Antibody (D-3) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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α-actinin-4 Antibody (D-3) is a mouse monoclonal IgM antibody that detects α-actinin-4 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). α-actinin-4 is a crucial member of the spectrin gene family, which encodes a variety of cytoskeletal proteins, including spectrins, dystrophins, and α-actinins. α-actinin-4 is primarily located in the cytoskeleton of muscle and non-muscle cells, where α-actinin-4 plays a vital role in maintaining cellular structure and integrity. Specifically, α-actinin-4 functions as a bundling protein that cross-links filamentous actin (F-actin), anchoring F-actin to various intracellular structures, which is essential for processes such as cell shape maintenance, motility, and signal transduction. Defects in the gene encoding α-actinin-4 have been linked to focal segmental glomerulosclerosis 1 (FSGS1), a significant renal condition characterized by progressive kidney dysfunction and potential renal failure. Anti-α-actinin-4 antibody (D-3) effectively detects α-actinin-4 across multiple species, making anti-α-actinin-4 antibody (D-3) an invaluable tool for researchers studying cytoskeletal dynamics and related pathologies.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
α-actinin-4 Antibody (D-3) | sc-398088 | 200 µg/ml | $322.00 | |||
α-actinin-4 Antibody (D-3): m-IgGκ BP-HRP Bundle | sc-552168 | 200 µg Ab; 40 µg BP | $361.00 | |||
α-actinin-4 (D-3) Neutralizing Peptide | sc-398088 P | 100 µg/0.5 ml | $69.00 |