α-2M Antibody (2D9): sc-69750

α-2M Antibody (2D9) is a mouse monoclonal IgG1 antibody that detects α-2-Macroglobulin in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. α-2-Macroglobulin (α-2M) is a homotetrameric serum protein composed of four identical subunits that are linked by disulfide bonds, forming dimers. α-2M plays a crucial role in the regulation of inflammatory responses by acting as a carrier protein for cytokines, particularly transforming growth factor β (TGFβ), which is primarily bound to α-2M in serum, rendering TGFβ inactive. α-2M′s ability to bind and sequester cytokines like interleukin-6 (IL-6) enhances their local concentration near immune cells, such as lymphocytes and hepatocytes, thereby amplifying the inflammatory cascade. Furthermore, α-2M is implicated in neurodegenerative diseases, as mutations in α-2M gene have been linked to an increased risk of Alzheimer′s Disease. This association highlights α-2M′s role in mediating the clearance of amyloid-beta, a key component of the plaques that accumulate in the brains of Alzheimer′s patients. With multifaceted roles in inflammation and neuroprotection, α-2M is a significant protein for research in both immunology and neurobiology, making anti-α-2M antibody (2D9) an essential tool for scientists studying these critical pathways.

The preferred α-2M antibody is α-2M Antibody (H-8): sc-390544.