ALP Antibody (C-8): sc-373737
- ALP Antibody (C-8) is a mouse monoclonal IgG1 κ, cited in 7 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 71-101 within an internal region of ALP of human origin
- recommended for detection of ALP of human origin by WB, IP, IF and ELISA
- m-IgG1 BP-HRP is the preferred secondary detection reagent for ALP Antibody (C-8) for WB applications. This reagent is now offered in a bundle with ALP Antibody (C-8) (see ordering information below).
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ALP Antibody (C-8) is a mouse monoclonal IgG1 antibody that detects ALP (actinin-associated LIM protein) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ALP is a 364 amino acid protein characterized by one LIM zinc-binding domain and one PDZ domain, primarily localized in the cytoplasm and at the Z-lines of myofibers, which are critical for muscle contraction and structural integrity. The presence of ALP at these locations is essential for the organization of actin filaments, as ALP interacts with α-actinin-2 to regulate the assembly and stability of actin filament arrays within muscle cells. This interaction is vital for maintaining muscle function, and any disruption in ALP′s role could contribute to muscle-related diseases. Notably, the gene encoding ALP is located on human chromosome 4, a region linked to facioscapulohumeral muscular dystrophy, indicating that mutations or defects in ALP may play a significant role in the pathogenesis of this condition. With insights into muscle biology and disease mechanisms, anti-ALP antibody (C-8) serves as an invaluable tool for researchers studying muscle development and disorders.
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ALP Antibody (C-8) References:
- Differential Properties of Human ALP+ Periodontal Ligament Stem Cells vs Their ALP- Counterparts. | Yu, Z., et al. 2015. J Stem Cell Res Ther. 5: PMID: 26807329
- ALP-activated probe for diagnosis of liver injury by multispectral optoacoustic tomography. | Wu, Y., et al. 2021. Methods Enzymol. 657: 301-330. PMID: 34353492
- Cross-sectional analysis: clinical presentation of children with persistently low ALP levels. | Semler, O., et al. 2021. J Pediatr Endocrinol Metab. 34: 1559-1566. PMID: 34428361
- Fluorescence recovery based on synergetic effect for ALP detection. | Huang, S., et al. 2022. Spectrochim Acta A Mol Biomol Spectrosc. 280: 121550. PMID: 35777229
- DPA promotes hBMSCs osteogenic differentiation by miR-9-5p/ERK/ALP signaling pathway. | Gao, X., et al. 2022. Int J Med Sci. 19: 1879-1887. PMID: 36438924
- ALP-Based Biosensors Employing Electrodes Modified with Carbon Nanomaterials for Pesticides Detection. | Gianvittorio, S., et al. 2023. Molecules. 28: PMID: 36838520
- RUNX2 and ALP expression in osteoblast cells exposed by PMMA-HAp combination: An in vitro study. | Darjanki, CM., et al. 2023. J Oral Biol Craniofac Res. 13: 277-282. PMID: 36896352
- ALP-assisted chemical redox cycling signal amplification for ultrasensitive fluorescence detection of DNA methylation. | Zhang, H., et al. 2023. Analyst. 148: 5753-5761. PMID: 37842979
- Emerging potential approaches in alkaline phosphatase (ALP) activatable cancer theranostics. | Tyagi, K. and Venkatesh, V. 2024. RSC Med Chem. 15: 1148-1160. PMID: 38665831
- Astragaloside IV Improves Muscle Atrophy by Modulating the Activity of UPS and ALP via Suppressing Oxidative Stress and Inflammation in Denervated Mice. | Liu, H., et al. 2024. Mol Neurobiol.. PMID: 39480556
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ALP Antibody (C-8) | sc-373737 | 200 µg/ml | $322.00 | |||
ALP Antibody (C-8): m-IgG1 BP-HRP Bundle | sc-542697 | 200 µg Ab; 20 µg BP | $361.00 | |||
ALP (C-8) Neutralizing Peptide | sc-373737 P | 100 µg/0.5 ml | $69.00 |