TNAP Antibody (D-3): sc-137213

TNAP Antibody (D-3) is a mouse monoclonal IgG1 antibody that detects tissue non-specific alkaline phosphatase (TNAP) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TNAP is a crucial enzyme that plays a significant role in bone mineralization, functioning alongside plasma cell membrane glycoprotein-1 to facilitate the deposition of minerals in the bone matrix. This process is vital for maintaining bone integrity and strength, and any disruption can lead to serious skeletal disorders. Notably, mutations or deficiencies in the TNAP gene are directly associated with hypophosphatasia, a rare genetic condition characterized by impaired bone mineralization and various skeletal abnormalities. TNAP is widely expressed in tissues such as the liver, kidney, and bone, highlighting TNAP′s importance in physiological processes across different organ systems. The human gene encoding TNAP is located on chromosome 1p36.1-p34, and understanding TNAP′s function and interactions is essential for elucidating the mechanisms underlying bone health and disease. Anti-TNAP antibody (D-3) provides a reliable tool for researchers investigating the role of this enzyme in various biological contexts.

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TNAP Antibody (D-3) References:

1. Rediscovering TNAP in the Brain: A Major Role in Regulating the Function and Development of the Cerebral Cortex.  |  Fonta, C., et al. 2015. Subcell Biochem. 76: 85-106. PMID: 26219708
2. TNAP, an Essential Player in Membrane Lipid Rafts of Neuronal Cells.  |  Ermonval, M., et al. 2015. Subcell Biochem. 76: 167-83. PMID: 26219712
3. TNAP Plays a Key Role in Neural Differentiation as well as in Neurodegenerative Disorders.  |  Diaz-Hernandez, M., et al. 2015. Subcell Biochem. 76: 375-85. PMID: 26219721
4. TNAP as a therapeutic target for cardiovascular calcification: a discussion of its pleiotropic functions in the body.  |  Goettsch, C., et al. 2022. Cardiovasc Res. 118: 84-96. PMID: 33070177
5. TNAP as a New Player in Chronic Inflammatory Conditions and Metabolism.  |  Graser, S., et al. 2021. Int J Mol Sci. 22: PMID: 33477631
6. TNAP is a novel regulator of cardiac fibrosis after myocardial infarction by mediating TGF-β/Smads and ERK1/2 signaling pathways.  |  Cheng, X., et al. 2021. EBioMedicine. 67: 103370. PMID: 33971401
7. Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine.  |  Sun, Y., et al. 2021. Nature. 593: 580-585. PMID: 33981039
8. NPP1 and TNAP hydrolyze ATP synergistically during biomineralization.  |  Andrilli, LHS., et al. 2023. Purinergic Signal. 19: 353-366. PMID: 35870033
9. ADRA1A-Gαq signalling potentiates adipocyte thermogenesis through CKB and TNAP.  |  Rahbani, JF., et al. 2022. Nat Metab. 4: 1459-1473. PMID: 36344764
10. TNAP and P2X7R: New Plasma Biomarkers for Alzheimer's Disease.  |  Aivar, P., et al. 2023. Int J Mol Sci. 24: PMID: 37446074

The preferred TNAP antibody is TNAP Antibody (F-4): sc-166261.