Alix Antibody (C-11): sc-271975

Alix Antibody (C-11) is a mouse monoclonal IgG2a kappa light chain antibody that detects Alix in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Alix antibody (C-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ALG-2-interacting protein, also known as programmed cell death 6-interacting protein, plays a crucial role in cellular processes by facilitating the sorting and concentration of cargo proteins within multivesicular bodies, which are essential for proper protein trafficking to lysosomes for degradation. This function maintains cellular homeostasis and regulates apoptosis by ensuring efficient removal of damaged or unneeded proteins from cells. Alix monoclonal antibody (C-11) recognizes a protein that interacts with several key partners, including apoptosis-associated proteins such as ALG-2 and PDCD6, as well as endocytosis regulators like CIN85. Additionally, Alix (C-11) antibody targets a protein that associates with endosomal sorting complexes required for transport (ESCRT) proteins, including Tsg101 and CHMP4, and has demonstrated interaction with HIV-1, highlighting significance in viral pathogenesis. Anti-Alix antibody (C-11) detects a protein that binds to endophilins, which are involved in membrane curvature and vesicle formation, underscoring critical roles in cellular dynamics and protein sorting.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Alix Antibody (C-11) has 31 citations in a variety of scientific publications.

Primary antibodies like Anti-Alix Antibody (C-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Alix Antibody (C-11) Specifications

Alternate Product Name: Alix

Product Clone Name: C-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 463-732

Epitope Target: Alix

Epitope Species: human

Product Reactivity/Detection: Alix

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 31 citations in various scientific publications

Available Conjugates/Forms for Alix Antibody (C-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Alix antibody is Alix Antibody (1A12): sc-53540.