ALG-2 Antibody (AA8): sc-101209
- ALG-2 Antibody (AA8) is a mouse monoclonal IgG2a κ provided at 100 µg/ml
- raised against recombinant ALG-2 of human origin
- recommended for detection of ALG-2 of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ALG-2 Antibody (AA8). This work is in progress.
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ALG-2 Antibody (AA8) is a mouse monoclonal IgG2a antibody that detects ALG-2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ALG-2, or apoptosis-linked gene 2, plays a crucial role in regulating apoptotic cell death, particularly in the context of increased intracellular calcium ion concentrations, which are essential for various signaling pathways, including those mediated by glucocorticoids and T cell receptors. ALG-2 is predominantly expressed in the brain, with significantly higher levels observed in ischemic conditions, highlighting potential involvement in neurodegenerative processes. Structurally, ALG-2 contains five EF-hand-like motifs, which are critical for calcium-binding capability, allowing ALG-2 to function effectively in cellular signaling and apoptosis regulation. This structural feature enables ALG-2 to interact with other proteins, such as members of the penta EF-hand family, including Calpain small subunits, sorcin, and Grancalcin, thereby influencing various cellular responses to stress and death signals. Anti-ALG-2 antibody (AA8) is an invaluable tool for researchers studying apoptosis and calcium signaling pathways in diverse biological contexts.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ALG-2 Antibody (AA8) | sc-101209 | 100 µg/ml | $339.00 |