Date published: 2026-5-9

1-800-457-3801

SCBT Portrait Logo
Seach Input

Alfuzosin hydrochloride (CAS 81403-68-1)

5.0(1)
Write a reviewAsk a question

Alternate Names:
Uroxatral; Urion; Xatral
Application:
Alfuzosin hydrochloride is an α 1 adrenoceptor antagonist
CAS Number:
81403-68-1
Purity:
≥99%
Molecular Weight:
425.91
Molecular Formula:
C19H27N5O4•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Alfuzosin hydrochloride is a uro-selective α 1 AR (adrenoceptor) antagonist that does not distinguish between α 1 subtypes. In addition, in vitro studies indicate that Alfuzosin hydrochloride can relax corpus cavernosum tissue. Also Alfuzosin hydrochloride has been seen to inhibit the increase of intraurethral pressure caused by phenylephrine. Studies suggest that isocratic reversed phase high-performance liquid chromatographic (HPLC) with ultraviolet detection at 245 nm can be used, along with a stainless steel analytical column to determine the presence of Alfuzosin hydrochloride in solution. Furthermore, alternate studies indicate that Alfuzosin hydrochloride can be detected in human plasma using a spectrofluorimetric method which relies on measuring the native fluorescence of Alfuzosin hydrochloride in deionized water using λ excitation at 325.0 nm and λ emission at 390.0 nm along with solid phase extraction.


Alfuzosin hydrochloride (CAS 81403-68-1) References

  1. Alfuzosin hydrochloride for the treatment of benign prostatic hyperplasia.  |  Lee, M. 2003. Am J Health Syst Pharm. 60: 1426-39. PMID: 12892027
  2. Extended-release alfuzosin hydrochloride: a new alpha-adrenergic receptor antagonist for symptomatic benign prostatic hyperplasia.  |  Guay, DR. 2004. Am J Geriatr Pharmacother. 2: 14-23. PMID: 15555475
  3. Stability-indicating spectrophotometric and spectrofluorimetric methods for determination of alfuzosin hydrochloride in the presence of its degradation products.  |  Fayed, AS., et al. 2007. Pharmazie. 62: 830-5. PMID: 18065098
  4. Quantitation of alfuzosin hydrochloride in pharmaceutical formulations by RP-HPLC.  |  Ganesh, M., et al. 2009. Pak J Pharm Sci. 22: 263-6. PMID: 19553171
  5. Alfuzosin hydrochloride transdermal films: evaluation of physicochemical, in vitro human cadaver skin permeation and thermodynamic parameters.  |  Pattnaik, S., et al. 2009. Int Braz J Urol. 35: 716-29. PMID: 20028577
  6. The Effects of Systemic Alfuzosin and Tamsulosin Hydrochloride on Choroidal Thickness and Pupil Diameter Sizes in Cases with Benign Prostatic Hyperplasia.  |  Dogan, M., et al. 2017. Curr Eye Res. 42: 1638-1643. PMID: 28937828
  7. Alfuzosin hydrochloride-loaded low-density gastroretentive sponges: development, in vitro characterization and gastroretentive monitoring in healthy volunteers via MRI.  |  Abd El-Aziz, MF., et al. 2020. Pharm Dev Technol. 25: 566-578. PMID: 31967910
  8. Utilization of a micellar matrix for simultaneous spectrofluorimetric estimation of alfuzosin hydrochloride and vardenafil hydrochloride.  |  Elama, HS., et al. 2022. Spectrochim Acta A Mol Biomol Spectrosc. 266: 120420. PMID: 34619505
  9. Green micellar liquid chromatographic analysis of alfuzosin hydrochloride and sildenafil citrate in a binary mixture compared to classical RPLC with stability indicating studies.  |  Ayad, MM., et al. 2022. Drug Dev Ind Pharm. 48: 41-51. PMID: 35754330
  10. Utilization of absorbance subtraction and ratio difference green spectrophotometric methods for the quantification of alfuzosin hydrochloride and tadalafil in their binary mixture.  |  Alqahtani, A., et al. 2024. BMC Chem. 18: 96. PMID: 38725069

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Alfuzosin hydrochloride, 10 mg

sc-203812
10 mg
$83.00

Alfuzosin hydrochloride, 50 mg

sc-203812A
50 mg
$307.00