Aldolase A Antibody (A-2): sc-377058

Aldolase A Antibody (A-2) is a mouse monoclonal IgG1 antibody that detects Aldolase A in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Aldolase A antibody (A-2) plays a crucial role in glycolysis, catalyzing the reversible condensation of glycerone phosphate and glyceraldehyde 3-phosphate into fructose 1,6-bisphosphate, a key intermediate in energy metabolism. Aldolase A (A-2) monoclonal antibody helps regulate the flow of carbon through the glycolytic pathway, which is essential for energy production in cells. Aldolase A (A-2) antibody is vital for maintaining energy homeostasis, especially in muscle tissues where Aldolase A is predominantly expressed. Dysregulation of Aldolase A can lead to metabolic disorders, highlighting its significance in both normal physiology and disease states. Anti-Aldolase A antibody (A-2) provides reliable detection and quantification of this important enzyme, facilitating research into its role in various biological processes and potential implications in metabolic diseases.

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Aldolase A Antibody (A-2) References:

1. Up-regulation of aldolase A and methylglyoxal production in adipocytes.  |  Liu, J., et al. 2013. Br J Pharmacol. 168: 1639-46. PMID: 23126339
2. Identification of aldolase A as a potential diagnostic biomarker for colorectal cancer based on proteomic analysis using formalin-fixed paraffin-embedded tissue.  |  Yamamoto, T., et al. 2016. Tumour Biol. 37: 13595-13606. PMID: 27468721
3. Aldolase A overexpression is associated with poor prognosis and promotes tumor progression by the epithelial-mesenchymal transition in colon cancer.  |  Ye, F., et al. 2018. Biochem Biophys Res Commun. 497: 639-645. PMID: 29453983
4. Aldolase A as a prognostic factor and mediator of progression via inducing epithelial-mesenchymal transition in gastric cancer.  |  Jiang, Z., et al. 2018. J Cell Mol Med. 22: 4377-4386. PMID: 29992789
5. Aldolase A promotes epithelial-mesenchymal transition to increase malignant potentials of cervical adenocarcinoma.  |  Saito, Y., et al. 2020. Cancer Sci. 111: 3071-3081. PMID: 32530543
6. Aldolase A Enhances Intrahepatic Cholangiocarcinoma Proliferation and Invasion through Promoting Glycolysis.  |  Li, X., et al. 2021. Int J Biol Sci. 17: 1782-1794. PMID: 33994862
7. Aldolase A and Phospholipase D1 Synergistically Resist Alkylating Agents and Radiation in Lung Cancer.  |  Chang, YC., et al. 2021. Front Oncol. 11: 811635. PMID: 35127525
8. Aldolase A Promotes Colorectal Cancer Progression through Targeting COPS6 and Regulating MAPK Signaling Pathway.  |  Lu, Y., et al. 2023. Dis Markers. 2023: 1702125. PMID: 37457886
9. The fructose-bisphosphate, Aldolase A (ALDOA), facilitates DNA-PKcs and ATM kinase activity to regulate DNA double-strand break repair.  |  Sobanski, T., et al. 2023. Sci Rep. 13: 15171. PMID: 37704669
10. Anticancer Peptides Derived from Aldolase A and Induced Tumor-Suppressing Cells Inhibit Pancreatic Ductal Adenocarcinoma Cells.  |  Cui, C., et al. 2023. Pharmaceutics. 15: PMID: 37896207

The preferred Aldolase A antibody is Aldolase A Antibody (C-10): sc-390733.