Aldehyde dehydrogenase 3-A1/ALDH3A1 Antibody (F-9): sc-515905
- Aldehyde dehydrogenase 3-A1/ALDH3A1 Antibody (F-9) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 430-453 at the C-terminus of ALDH3A1 of mouse origin
- recommended for detection of ALDH3A1 of mouse origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Aldehyde dehydrogenase 3-A1/ALDH3A1 Antibody (F-9). This work is in progress.
ALDH3A1 Antibody (F-9) is a mouse monoclonal IgG2a antibody that detects aldehyde dehydrogenase 3A1 (ALDH3A1) in mouse samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). ALDH3A1 plays a crucial role in the metabolism of aldehydes, particularly in the oxidation of aromatic aldehydes, which is essential for detoxifying harmful compounds and maintaining cellular homeostasis. ALDH3A1 is predominantly located in the cytoplasm, where ALDH3A1 forms a homodimer that enhances enzymatic activity, making ALDH3A1 vital for protecting cells from oxidative stress and damage. Expression of ALDH3A1 is notably upregulated in response to oxidative stress, and ALDH3A1 is often associated with certain tumors that exhibit increased metabolic rates, particularly in the context of chemotherapy resistance. Anti-ALDH3A1 antibody (F-9) enables researchers to gain insights into the functional dynamics of this important enzyme and its implications in cancer biology and metabolic disorders.
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Aldehyde dehydrogenase 3-A1/ALDH3A1 Antibody (F-9) References:
- Four amino acid changes are associated with the Aldh3a1 locus polymorphism in mice which may be responsible for corneal sensitivity to ultraviolet light. | Shiao, T., et al. 1999. Pharmacogenetics. 9: 145-53. PMID: 10376761
- Three different stable human breast adenocarcinoma sublines that overexpress ALDH3A1 and certain other enzymes, apparently as a consequence of constitutively upregulated gene transcription mediated by transactivated EpREs (electrophile responsive elements) present in the 5'-upstream regions of these genes. | Sreerama, L. and Sládek, NE. 2001. Chem Biol Interact. 130-132: 247-60. PMID: 11306049
- The oxidation status of ALDH3A1 in human saliva and its correlation with antioxidant capacity measured by ORAC method. | Bogucka, M., et al. 2009. Acta Pol Pharm. 66: 477-82. PMID: 19894643
- Aldehyde dehydrogenase 3A1 promotes multi-modality resistance and alters gene expression profile in human breast adenocarcinoma MCF-7 cells. | Voulgaridou, GP., et al. 2016. Int J Biochem Cell Biol. 77: 120-128. PMID: 27276244
- Human aldehyde dehydrogenase 3A1 (ALDH3A1) exhibits chaperone-like function. | Voulgaridou, GP., et al. 2017. Int J Biochem Cell Biol. 89: 16-24. PMID: 28526614
- Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes. | Saiki, JP., et al. 2018. Proc Natl Acad Sci U S A. 115: 6279-6284. PMID: 29794221
- Inhibition of Wnt/beta-catenin signaling downregulates expression of aldehyde dehydrogenase isoform 3A1 (ALDH3A1) to reduce resistance against temozolomide in glioblastoma in vitro. | Suwala, AK., et al. 2018. Oncotarget. 9: 22703-22716. PMID: 29854309
- Shikonin enhances the antitumor effect of cabazitaxel in prostate cancer stem cells and reverses cabazitaxel resistance by inhibiting ABCG2 and ALDH3A1. | Wang, L., et al. 2020. Am J Cancer Res. 10: 3784-3800. PMID: 33294267
- Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell phenotype. | Viswanathan, V., et al. 2022. PNAS Nexus. 1: pgac056. PMID: 35707206
- Investigating the Functional Roles of Aldehyde Dehydrogenase 3A1 in Human Corneal Epithelial Cells. | Voulgaridou, GP., et al. 2023. Int J Mol Sci. 24: PMID: 36982917
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Aldehyde dehydrogenase 3-A1/ALDH3A1 Antibody (F-9) | sc-515905 | 200 µg/ml | $316.00 |