ALCAM Antibody (H-9): sc-74557
- ALCAM Antibody (H-9) is a mouse monoclonal IgG2b κ, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 28-135 mapping near the N-terminus of ALCAM of human origin
- recommended for detection of ALCAM of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See ALCAM (B-6): sc-74558 for ALCAM antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG2b BP-HRP is the preferred secondary detection reagent for ALCAM Antibody (H-9) for WB and IHC(P) applications. This reagent is now offered in a bundle with ALCAM Antibody (H-9) (see ordering information below).
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ALCAM Antibody (H-9) is a mouse monoclonal IgG2b antibody that detects activated leukocyte cell adhesion molecule (ALCAM) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). ALCAM plays a crucial role in immune responses by facilitating the adhesion of activated leukocytes, such as T cells, B cells, and monocytes, to other cells, which is essential for effective immune surveillance and response. ALCAM is primarily located on the surface of activated leukocytes, where anti-ALCAM antibody (H-9) can detect both homophilic interactions with other ALCAM molecules and heterophilic interactions with CD6, a type I membrane protein that enhances T cell adhesion and costimulation. The interaction between ALCAM and CD6 is particularly significant as ALCAM contributes to the formation of immunological synapses, which are critical for T cell activation and function. ALCAM (H-9) antibody enables researchers to gain insights into the mechanisms of immune cell interactions and their implications in various diseases, including autoimmune disorders and cancer.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ALCAM Antibody (H-9) References:
- Activated leukocyte cell adhesion molecule (ALCAM or CD166) modulates bone phenotype and hematopoiesis. | Hooker, RA., et al. 2015. J Musculoskelet Neuronal Interact. 15: 83-94. PMID: 25730656
- Activated Leukocyte Cell Adhesion Molecule Stimulates the T-Cell Response in Allergic Asthma. | Kim, MN., et al. 2018. Am J Respir Crit Care Med. 197: 994-1008. PMID: 29394080
- Activated Leukocyte Cell Adhesion Molecule Modulates Th2 Immune Response in Atopic Dermatitis. | Oh, MS., et al. 2019. Allergy Asthma Immunol Res. 11: 677-690. PMID: 31332979
- The role of activated leukocyte cell adhesion molecule (ALCAM) in cancer progression, invasion, metastasis and recurrence: A novel cancer stem cell marker and tumor-specific prognostic marker. | Darvishi, B., et al. 2020. Exp Mol Pathol. 115: 104443. PMID: 32380056
- ALCAM/CD166: A pleiotropic mediator of cell adhesion, stemness and cancer progression. | Ferragut, F., et al. 2021. Cytokine Growth Factor Rev. 61: 27-37. PMID: 34272152
- The Clinical and Theranostic Values of Activated Leukocyte Cell Adhesion Molecule (ALCAM)/CD166 in Human Solid Cancers. | Yang, Y., et al. 2021. Cancers (Basel). 13: PMID: 34680335
- The CD6/ALCAM pathway promotes lupus nephritis via T cell-mediated responses. | Chalmers, SA., et al. 2022. J Clin Invest. 132: PMID: 34981775
- Activated leukocyte cell adhesion molecule (ALCAM)/CD166 in pancreatic cancer, a pivotal link to clinical outcome and vascular embolism. | Yang, Y., et al. 2021. Am J Cancer Res. 11: 5917-5932. PMID: 35018233
- Activated Leukocyte Cell Adhesion Molecule (ALCAM), a Potential 'Seed' and 'Soil' Receptor in the Peritoneal Metastasis of Gastrointestinal Cancers. | Yang, YM., et al. 2023. Int J Mol Sci. 24: PMID: 36614319
- ALCAM, Activated Leukocyte Cell Adhesion Molecule, in Clinical Gastric Cancer and Patient's Response to Chemotherapies. | Yang, YM., et al. 2023. Anticancer Res. 43: 1463-1475. PMID: 36974802
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ALCAM Antibody (H-9) | sc-74557 | 200 µg/ml | $322.00 | |||
ALCAM Antibody (H-9): m-IgG2b BP-HRP Bundle | sc-548462 | 200 µg Ab; 10 µg BP | $361.00 |