Akt1/2/3 Antibody (BDI111): sc-56878

Akt1/2/3 Antibody (BDI111) is a mouse monoclonal IgG1 antibody that detects Akt1/2/3 in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Akt1/2/3, members of the serine/threonine kinase Akt family, play a crucial role in various cellular processes, including metabolism, cell proliferation, and survival, making Akt1/2/3 vital for maintaining cellular homeostasis and responding to growth factor signals. The structure of Akt proteins is characterized by a pleckstrin homology domain, which is essential for Akt protein activation and localization to the plasma membrane upon stimulation by growth factors like insulin and platelet-derived growth factor (PDGF). This structural feature allows Akt proteins to interact with phosphoinositides, facilitating recruitment to the membrane where phosphorylation and activation by upstream kinases occur. The phosphorylation of specific residues, such as Thr 308 and Ser 473, is critical for achieving full enzymatic activity, underscoring the importance of Akt′s structural integrity in function. Anti-Akt1/2/3 antibody (BDI111) is an invaluable tool for researchers studying the intricate signaling pathways involving Akt and their implications in various diseases, including cancer and metabolic disorders.

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Akt1/2/3 Antibody (BDI111) References:

1. Sorafenib downregulates ERK/Akt and STAT3 survival pathways and induces apoptosis in a human neuroblastoma cell line.  |  Chai, H., et al. 2010. Int J Clin Exp Pathol. 3: 408-15. PMID: 20490331
2. Proliferation of the human urothelium is induced by atypical β1 -adrenoceptors.  |  Winder, M., et al. 2015. Auton Autacoid Pharmacol. 35: 32-40. PMID: 26913580
3. Anticancer effects of morin-7-sulphate sodium, a flavonoid derivative, in mouse melanoma cells.  |  Li, HW., et al. 2016. Biomed Pharmacother. 84: 909-916. PMID: 27764752
4. The effect of interleukin 6 deficiency on myocardial signal transduction pathways activation induced by bacterial lipopolysaccharide in young and old mice.  |  Tarasiuk, E., et al. 2020. Adv Med Sci. 65: 386-393. PMID: 32693349
5. The Role of Akt in Acquired Cetuximab Resistant Head and Neck Squamous Cell Carcinoma: An In Vitro Study on a Novel Combination Strategy.  |  Zaryouh, H., et al. 2021. Front Oncol. 11: 697967. PMID: 34568028
6. Synergistic cytotoxicity of the CDK4 inhibitor Fascaplysin in combination with EGFR inhibitor Afatinib against Non-small Cell Lung Cancer.  |  Plangger, A., et al. 2022. Invest New Drugs. 40: 215-223. PMID: 34596822
7. Adipocyte and Adipokines Promote a Uterine Leiomyoma Friendly Microenvironment.  |  Afrin, S., et al. 2023. Nutrients. 15: PMID: 36771423
8. H2S regulates redox signaling downstream of cardiac β-adrenergic receptors in a G6PD-dependent manner.  |  Chhabra, A., et al. 2023. Cell Signal. 107: 110664. PMID: 37004833
9. Redundant roles of AKT1 and AKT2 in fertility, estrous cyclicity and endometrial gland development.  |  Adam, P., et al. 2023. Reproduction. 165: 605-616. PMID: 37053038
10. AKT1 Promotes Tumorigenesis and Metastasis by Directly Phosphorylating Hexokinases.  |  Yu, Y., et al. 2024. J Cell Biochem. 125: e30613. PMID: 38860522

The preferred Akt1 antibody is Akt1 Antibody (B-1): sc-5298.