AKR1A1 Antibody (B-10): sc-374204
- AKR1A1 Antibody (B-10) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 205-231 within an internal region of AKR1A1 of human origin
- recommended for detection of AKR1A1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including canine
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for AKR1A1 Antibody (B-10) for WB and IHC(P) applications. These reagents are now offered in bundles with AKR1A1 Antibody (B-10) (see ordering information below).
AKR1A1 Antibody (B-10) is a mouse monoclonal IgG1 antibody that detects AKR1A1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). AKR1A1, also known as aldo-keto reductase family 1 member A1, aldehyde reductase, dihydrodiol dehydrogenase 3, or alcohol dehydrogenase, is a crucial enzyme within the aldo-keto reductase family, which consists of soluble NADPH-dependent oxidoreductases that are vital for the metabolism of drugs, carcinogens, and reactive aldehydes. AKR1A1 primarily functions as a monomer, catalyzing the reduction of both xenobiotic and biogenic aldehydes and ketones to their corresponding alcohols, with a particular efficiency for medium-chain and aromatic aldehydes. Notably, AKR1A1 is involved in the biosynthetic pathways of cholesterol and triglycerides, highlighting its importance in lipid metabolism. Additionally, AKR1A1 plays a significant role in the activation of polycyclic aromatic hydrocarbons (PAHs), which are known to be environmental pollutants and potential carcinogens. The ability of AKR1A1 to modulate these pathways underscores its relevance in both normal physiological processes and in the context of disease, making anti-AKR1A1 antibody (B-10) an essential tool for researchers studying metabolic pathways and toxicology.
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AKR1A1 Antibody (B-10) References:
- Interindividual variability in the cardiac expression of anthracycline reductases in donors with and without Down syndrome. | Quiñones-Lombraña, A., et al. 2014. Pharm Res. 31: 1644-55. PMID: 24562808
- Identification of S-nitroso-CoA reductases that regulate protein S-nitrosylation. | Anand, P., et al. 2014. Proc Natl Acad Sci U S A. 111: 18572-7. PMID: 25512491
- Carbonyl-reducing enzymes as targets of a drug-immobilised affinity carrier. | Andrýs, R., et al. 2015. Chem Biol Interact. 234: 169-77. PMID: 25595226
- Pharmacokinetic interactions of breast cancer chemotherapeutics with human doxorubicin reductases. | Hofman, J., et al. 2015. Biochem Pharmacol. 96: 168-78. PMID: 25986883
- Adipocytes Sequester and Metabolize the Chemotherapeutic Daunorubicin. | Sheng, X., et al. 2017. Mol Cancer Res. 15: 1704-1713. PMID: 29117945
- Dimeric dihydrodiol dehydrogenase is an efficient primate 1,5-anhydro-D-fructose reductase. | Hara, A., et al. 2020. Biochem Biophys Res Commun. 526: 728-732. PMID: 32253031
- Global landscape of protein complexes in postprandial-state livers from diet-induced obese and lean mice. | Kim, SQ., et al. 2022. Biochem Biophys Res Commun. 629: 40-46. PMID: 36099783
- Relevance of Human Aldoketoreductases and Microbial β-Glucuronidases in Testosterone Disposition. | Basit, A., et al. 2023. Drug Metab Dispos. 51: 427-435. PMID: 36623880
- Quantitative Analysis of mRNA and Protein Expression Levels of Aldo-Keto Reductase and Short-Chain Dehydrogenase/Reductase Isoforms in the Human Intestine. | Hirosawa, K., et al. 2023. Drug Metab Dispos. 51: 1569-1577. PMID: 37722844
- Human exposure to diesel exhaust induces CYP1A1 expression and AhR activation without a coordinated antioxidant response. | Friberg, M., et al. 2023. Part Fibre Toxicol. 20: 47. PMID: 38062420
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AKR1A1 Antibody (B-10) | sc-374204 | 200 µg/ml | $322.00 | |||
AKR1A1 Antibody (B-10): m-IgG Fc BP-HRP Bundle | sc-537934 | 200 µg Ab; 10 µg BP | $361.00 | |||
AKR1A1 Antibody (B-10): m-IgGκ BP-HRP Bundle | sc-535417 | 200 µg Ab; 40 µg BP | $361.00 | |||
AKR1A1 Antibody (B-10): m-IgG1 BP-HRP Bundle | sc-545456 | 200 µg Ab; 20 µg BP | $361.00 | |||
AKR1A1 (B-10) Neutralizing Peptide | sc-374204 P | 100 µg/0.5 ml | $69.00 |