AKAP 8L Antibody (A-1): sc-376630

AKAP 8L Antibody (A-1) is a mouse monoclonal IgG3 kappa light chain antibody that detects AKAP 8L protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-AKAP 8L antibody (A-1) is available as a non-conjugated format. AKAP 8L protein, also known as HA95 or NAKAP95, is a crucial nuclear matrix protein that plays a significant role in cellular processes, particularly during mitosis. AKAP 8L is predominantly expressed in vital organs such as the liver, heart, pancreas, kidney, and skeletal muscle, where AKAP 8L is involved in the regulation of various signaling pathways. AKAP 8L interacts with histone deacetylase 3 (HDAC3) and AKAP 8, which is essential for the deacetylation of Histone H3 during mitotic progression. This post-translational modification is critical as AKAP 8L influences chromatin structure and gene expression, thereby impacting cell cycle regulation and cellular differentiation. AKAP 8L forms complexes with other proteins, underscoring AKAP 8L′s importance in maintaining the specificity and efficiency of signaling pathways within the cell, making AKAP 8L a valuable target for research in cell biology and cancer studies.

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AKAP 8L Antibody (A-1) References:

1. The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in chromatin condensation at mitosis.  |  Collas, P., et al. 1999. J Cell Biol. 147: 1167-80. PMID: 10601332
2. cDNA cloning of a novel human gene NAKAP95, neighbor of A-kinase anchoring protein 95 (AKAP95) on chromosome 19p13.11-p13.12 region.  |  Seki, N., et al. 2000. J Hum Genet. 45: 31-7. PMID: 10697960
3. A novel shuttle protein binds to RNA helicase A and activates the retroviral constitutive transport element.  |  Westberg, C., et al. 2000. J Biol Chem. 275: 21396-401. PMID: 10748171
4. Identification, cloning and characterization of a novel nuclear protein, HA95, homologous to A-kinase anchoring protein 95.  |  Orstavik, S., et al. 2000. Biol Cell. 92: 27-37. PMID: 10761695
5. A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95.  |  Arsenijevic, T., et al. 2004. Biochem J. 378: 673-9. PMID: 14641107
6. A-kinase-anchoring protein 95 functions as a potential carrier for the nuclear translocation of active caspase 3 through an enzyme-substrate-like association.  |  Kamada, S., et al. 2005. Mol Cell Biol. 25: 9469-77. PMID: 16227597
7. Interaction between fidgetin and protein kinase A-anchoring protein AKAP95 is critical for palatogenesis in the mouse.  |  Yang, Y., et al. 2006. J Biol Chem. 281: 22352-22359. PMID: 16751186
8. A-kinase anchoring proteins: a key to selective activation of cAMP-responsive events?  |  Coghlan, VM., et al. 1993. Mol Cell Biochem. 127-128: 309-19. PMID: 7935359

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-AKAP 8L Antibody (A-1) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-AKAP 8L Antibody (A-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

AKAP 8L Antibody (A-1) Specifications

Alternate Product Name: AKAP 8L

Product Clone Name: A-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 617-647

Epitope Target: AKAP 8L

Epitope Species: human

Product Reactivity/Detection: AKAP 8L

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for AKAP 8L Antibody (A-1): P: Blocking Peptide