Anti-AKAP 10 Antibody (C-8) is a mouse monoclonal IgG1 (kappa light chain) AKAP 10 antibody provided at 200 µg/ml
raised against amino acids 508-662 mapping at the C-terminus of AKAP 10 of human origin
Anti-AKAP 10 Antibody (C-8) is recommended for detection of AKAP 10 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
Anti-AKAP 10 Antibody (C-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
See m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP), our highly recommended recombinant alternative to conventional secondary anti-mouse IgG reagents.
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of AKAP 10 (C-8): sc-271074.
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
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SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
AKAP 10 Antibody (C-8) is a high quality monoclonal AKAP 10 antibody (also designated AKAP 10 antibody) suitable for the detection of the AKAP 10 protein of mouse, rat and human origin. AKAP 10 Antibody (C-8) is available as both the non-conjugated anti-AKAP 10 antibody form, as well as multiple conjugated forms of anti-AKAP 10 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The type II cAMP-protein kinase (PKA) is a multifunctional kinase with a broad range of substrates. Specificity of PKA signaling is thought to be mediated by the compartmentalization of the kinase to specific sites within the cell. To maintain this specific localization, the regulatory (R) subunits (RI and RII) of PKA interact with specific R-anchoring proteins designated AKAPs (A-kinase anchoring proteins). AKAP 10 (A kinase anchor protein 10), also known as PRKA10 or D-AKAP2 (dual-specific A kinase-anchoring protein 2), is a 662 amino acid mitochondrial membrane protein that belongs to the AKAP family. AKAP 10 is a dual specificity protein that binds to both type I and type II regulatory subunits of PKA and anchors them to the plasma membrane or the mitochondria. When anchored to the mitochondria, PKA can phosphorylate and, thus, inactivate the proapoptotic protein Bad. This suggests that AKAP 10 indirectly regulates Bad-induced apoptosis by mediating the mitochondrial attachment of PKA. Additionally, AKAP 10 may facilitate G-protein coupled signal transduction and could act as an adaptor in the assembly of multiprotein complexes.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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