AIP1 Antibody (E-8): sc-514766
- AIP1 Antibody (E-8) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 934-956 within an internal region of AIP1 of human origin
- recommended for detection of AIP1 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG2a BP-HRP is the preferred secondary detection reagent for AIP1 Antibody (E-8) for WB applications. This reagent is now offered in a bundle with AIP1 Antibody (E-8) (see ordering information below).
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AIP1 Antibody (E-8) is a mouse monoclonal IgG2a antibody that detects AIP1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). AIP1, also known as DAB2IP, is a 1,189 amino acid protein that plays a crucial role in cellular signaling by acting as a Ras GTPase-activating protein. AIP1 (E-8) antibody helps researchers study AIP1′s interaction with ASK1, which disrupts the association of ASK1 with an inhibitory 14-3-3 complex, thereby allowing ASK1 to exert pro-apoptotic functions within the cell. This mechanism is vital for regulating cell survival and apoptosis, especially in cancer, where AIP1 is down-regulated in prostate cancer tissues, suggesting a potential role as a tumor suppressor. Additionally, chromosomal aberrations in the gene encoding AIP1 have been linked to acute myeloid leukemia, highlighting AIP1′s importance in tumorigenesis and the potential implications of fusion proteins in cancer development. Anti-AIP1 antibody (E-8) serves as an essential tool for researchers investigating AIP1′s complex roles in various biological processes and diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AIP1 Antibody (E-8) | sc-514766 | 200 µg/ml | $322.00 | |||
AIP1 Antibody (E-8): m-IgG2a BP-HRP Bundle | sc-546079 | 200 µg Ab; 10 µg BP | $361.00 | |||
AIP1 (E-8) Neutralizing Peptide | sc-514766 P | 100 µg/0.5 ml | $69.00 |