AIF Antibody (E-11): sc-390619
- AIF Antibody (E-11) is a mouse monoclonal IgM κ, cited in 6 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 586-612 at the C-terminus of AIF of mouse origin
- recommended for detection of AIF of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- See AIF (E-1): sc-13116 for AIF antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for AIF Antibody (E-11). This work is in progress.
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AIF Antibody (E-11) is a mouse monoclonal IgM kappa light chain antibody specific for an epitope mapping between amino acids 586-612 at the C-terminus of Apoptosis-Inducing Factor (AIF) of mouse origin. AIF monoclonal antibody (E-11) detects AIF from mouse, rat, and human origins by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA); AIF monoclonal antibody (E-11) is also reactive with additional species including equine, canine, bovine, and porcine. AIF, also known as AIFM1 or PDCD8 (Programmed Cell Death Protein 8), is a flavoprotein located in the mitochondrial intermembrane space, characterized by FAD- and NADH-binding domains that contribute to oxidoreductase activity. AIF′s structure facilitates a dual role in mitochondrial energy metabolism and apoptosis; upon apoptotic stimuli, AIF translocates from mitochondria to nucleus where AIF induces chromatin condensation and large-scale DNA fragmentation, leading to programmed cell death. Understanding AIF′s structure and localization is important because dysregulation of AIF function has been implicated in various pathological conditions including neurodegenerative diseases and cancer. Anti-AIF antibody (E-11) is a valuable tool for researchers studying mechanisms of apoptosis and mitochondrial biology, providing high specificity and affinity for reliable detection of AIF across multiple species and experimental applications. AIF monoclonal antibody (E-11) aids in advancing research into cell death pathways and their implications in human health and disease by targeting the C-terminal region.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AIF Antibody (E-11) | sc-390619 | 200 µg/ml | $322.00 | |||
AIF (E-11) Neutralizing Peptide | sc-390619 P | 100 µg/0.5 ml | $69.00 |