AIDA-1 Antibody (C-10): sc-376610
- AIDA-1 Antibody (C-10) is a mouse monoclonal IgG1 κ AIDA-1 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 847-1054 mapping near the C-terminus of AIDA-1 of human origin
- AIDA-1 Antibody (C-10) is recommended for detection of AIDA-1 of human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine and canine
- Anti-AIDA-1 Antibody (C-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for AIDA-1 Antibody (C-10) for WB applications. These reagents are now offered in bundles with AIDA-1 Antibody (C-10) (see ordering information below).
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AIDA-1 Antibody (C-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects AIDA-1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). AIDA-1 (C-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. AIDA-1 plays a crucial role in the brain, where AIDA-1 is highly expressed and regulated by the β-Amyloid protein precursor (AbPP). AIDA-1 is involved in several important cellular processes, including the regulation of pre-mRNA splicing through AIDA-1′s interaction with coilin in Cajal bodies, which are essential for the assembly and modification of RNA. This interaction is vital for maintaining proper gene expression and cellular function, particularly in the context of neuronal development and health. Additionally, AIDA-1′s association with AbPP suggests involvement in the pathways related to Alzheimer′s disease, highlighting significance in neurodegenerative research.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
AIDA-1 Antibody (C-10) References:
- EB-1, a tyrosine kinase signal transduction gene, is transcriptionally activated in the t(1;19) subset of pre-B ALL, which express oncoprotein E2a-Pbx1. | Fu, X., et al. 1999. Oncogene. 18: 4920-9. PMID: 10490826
- Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia. | Wiemels, JL., et al. 2002. Proc Natl Acad Sci U S A. 99: 15101-6. PMID: 12415113
- Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule. | Petersen, HH., et al. 2003. J Cell Sci. 116: 453-61. PMID: 12508107
- E2A basic helix-loop-helix transcription factors in human leukemia. | LeBrun, DP. 2003. Front Biosci. 8: s206-22. PMID: 12700034
- Regulation of amyloid precursor protein expression and secretion via activation of ERK1/2 by hepatocyte growth factor in HEK293 cells transfected with APP751. | Liu, F., et al. 2003. Exp Cell Res. 287: 387-96. PMID: 12837293
- The intracellular localization of amyloid beta protein precursor (AbetaPP) intracellular domain associated protein-1 (AIDA-1) is regulated by AbetaPP and alternative splicing. | Ghersi, E., et al. 2004. J Alzheimers Dis. 6: 67-78. PMID: 15004329
- The anxiolytic-like activity of AIDA (1-aminoindan-1,5-dicarboxylic acid), an mGLu 1 receptor antagonist. | Kłodzińska, A., et al. 2004. J Physiol Pharmacol. 55: 113-26. PMID: 15082872
- Amyloid-beta protein precursor (AbetaPP) intracellular domain-associated protein-1 proteins bind to AbetaPP and modulate its processing in an isoform-specific manner. | Ghersi, E., et al. 2004. J Biol Chem. 279: 49105-12. PMID: 15347684
- A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin. | Xu, H. and Hebert, MD. 2005. BMC Cell Biol. 6: 23. PMID: 15862129
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AIDA-1 Antibody (C-10) | sc-376610 | 200 µg/ml | $322.00 | |||
AIDA-1 Antibody (C-10): m-IgG Fc BP-HRP Bundle | sc-527541 | 200 µg Ab; 10 µg BP | $361.00 | |||
AIDA-1 Antibody (C-10): m-IgG1 BP-HRP Bundle | sc-532914 | 200 µg Ab; 20 µg BP | $361.00 | |||
AIDA-1 Antibody (C-10) AC | sc-376610 AC | 500 µg/ml, 25% agarose | $424.00 | |||
AIDA-1 Antibody (C-10) HRP | sc-376610 HRP | 200 µg/ml | $322.00 | |||
AIDA-1 Antibody (C-10) FITC | sc-376610 FITC | 200 µg/ml | $336.00 | |||
AIDA-1 Antibody (C-10) PE | sc-376610 PE | 200 µg/ml | $349.00 | |||
AIDA-1 Antibody (C-10) Alexa Fluor® 488 | sc-376610 AF488 | 200 µg/ml | $364.00 | |||
AIDA-1 Antibody (C-10) Alexa Fluor® 546 | sc-376610 AF546 | 200 µg/ml | $364.00 | |||
AIDA-1 Antibody (C-10) Alexa Fluor® 594 | sc-376610 AF594 | 200 µg/ml | $364.00 | |||
AIDA-1 Antibody (C-10) Alexa Fluor® 647 | sc-376610 AF647 | 200 µg/ml | $364.00 | |||
AIDA-1 Antibody (C-10) Alexa Fluor® 680 | sc-376610 AF680 | 200 µg/ml | $364.00 | |||
AIDA-1 Antibody (C-10) Alexa Fluor® 790 | sc-376610 AF790 | 200 µg/ml | $364.00 |