AGRP Antibody (MM0085-32B12): sc-517457

AGRP Antibody (MM0085-32B12) is a mouse monoclonal IgG2 antibody that detects AGRP of human origin by western blotting (WB) and immunoprecipitation (IP). AGRP monoclonal antibody (MM0085-32B12) is available in a non-conjugated form, allowing for versatile applications in research. The agouti-related protein (AGRP) plays a crucial role in the regulation of energy homeostasis and body weight by acting as a potent antagonist of the melanocortin receptors MC3R and MC4R, which are involved in appetite control and energy expenditure. This regulation is particularly important as it links the central nervous system′s signaling pathways to peripheral metabolic processes, influencing feeding behavior and energy balance. AGRP is primarily expressed in the adrenal gland, subthalamic nucleus, and hypothalamus, with lower expression levels found in the testis, lung, and kidney. The gene encoding AGRP is located on human chromosome 16q22, and its expression is tightly regulated, reflecting the body′s need to maintain energy homeostasis. Understanding the function of AGRP and its interactions with melanocortin receptors is vital for developing therapeutic strategies for obesity and metabolic disorders.

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AGRP Antibody (MM0085-32B12) References:

1. Plasma levels of agouti-related protein are increased in obese men.  |  Katsuki, A., et al. 2001. J Clin Endocrinol Metab. 86: 1921-4. PMID: 11344185
2. Time and metabolic state-dependent effects of GLP-1R agonists on NPY/AgRP and POMC neuronal activity in vivo.  |  Dong, Y., et al. 2021. Mol Metab. 54: 101352. PMID: 34626854
3. Deficiency of ER Ca2+ sensor STIM1 in AgRP neurons confers protection against dietary obesity.  |  Chen, Z., et al. 2021. Cell Rep. 37: 109868. PMID: 34686338
4. AgRP/NPY and POMC neurons in the arcuate nucleus and their potential role in treatment of obesity.  |  Vohra, MS., et al. 2022. Eur J Pharmacol. 915: 174611. PMID: 34798121
5. Arcuate AgRP, but not POMC neurons, modulate paraventricular CRF synthesis and release in response to fasting.  |  Fernandes, ACA., et al. 2022. Cell Biosci. 12: 118. PMID: 35902915
6. Agrp-negative arcuate NPY neurons drive feeding under positive energy balance via altering leptin responsiveness in POMC neurons.  |  Qi, Y., et al. 2023. Cell Metab. 35: 979-995.e7. PMID: 37201523
7. GIRK2 potassium channels expressed by the AgRP neurons decrease adiposity and body weight in mice.  |  Oh, Y., et al. 2023. PLoS Biol. 21: e3002252. PMID: 37594983
8. Melanocortin-3 receptor expression in AgRP neurons is required for normal activation of the neurons in response to energy deficiency.  |  Gui, Y., et al. 2023. Cell Rep. 42: 113188. PMID: 37792535
9. Jinkui Shenqi pills ameliorate diabetes by regulating hypothalamic insulin resistance and POMC/AgRP expression and activity.  |  Zhang, S., et al. 2024. Phytomedicine. 126: 155297. PMID: 38342019
10. Molecular structure and chromosomal mapping of the human homolog of the agouti gene.  |  Kwon, HY., et al. 1994. Proc Natl Acad Sci U S A. 91: 9760-4. PMID: 7937887
11. Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice.  |  Shutter, JR., et al. 1997. Genes Dev. 11: 593-602. PMID: 9119224
12. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein.  |  Ollmann, MM., et al. 1997. Science. 278: 135-8. PMID: 9311920

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-AGRP Antibody (MM0085-32B12) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-AGRP Antibody (MM0085-32B12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

AGRP Antibody (MM0085-32B12) Specifications

Alternate Product Name: AGRP

Product Clone Name: MM0085-32B12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₂

Amino Acids:

Epitope Target: AgRP

Epitope Species: human

Product Reactivity/Detection: AGRP

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₂ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for AGRP Antibody (MM0085-32B12): N/A

The preferred AGRP antibody is AGRP Antibody (H-5): sc-518077.