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Agmatine sulfate (CAS 2482-00-0)

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Alternate Names:
(4-Aminobutyl)guanidine sulfate; 1-AMINO-4-GUANIDINOBUTANE SULFATE SALT; 4-GUANIDINO-BUTYLAMINE SULFATE
Application:
Agmatine sulfate is an L-arginine decarboxy analog with neurotransmiter activity
CAS Number:
2482-00-0
Purity:
≥98%
Molecular Weight:
228.27
Molecular Formula:
C5H14N4•H2SO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Agmatine sulfate is the sulfate preparation of Agmatine, the decarboxylated form of L-arginine and an endogenous metabolic product highly conserved across life forms. Agmatine is an intermediate in the biosynthesis of the polyamines putrescine and spermine. Agmatine binds with high affinity to α2-adrenergic receptors and imidazoline binding sites and produces blockade of the NMDA-receptor associated cation channels. The further observations that Agmatine is also stored in synaptic vesicles, is specifically degraded by agmatinase, and is released from axon terminals by depolarization all suggest that Agmatine has endogenous function as a neurotransmitter. Agmatine is a competitive inhibitor of NOS (nitric oxide synthase) activity owing to mimicry of the natural NOS substrate arginine.


Agmatine sulfate (CAS 2482-00-0) References

  1. Is agmatine a novel neurotransmitter in brain?  |  Reis, DJ. and Regunathan, S. 2000. Trends Pharmacol Sci. 21: 187-93. PMID: 10785653
  2. Agmatine suppresses nitric oxide production in microglia.  |  Abe, K., et al. 2000. Brain Res. 872: 141-8. PMID: 10924686
  3. Agmatine enhances the NADPH oxidase activity of neuronal NO synthase and leads to oxidative inactivation of the enzyme.  |  Demady, DR., et al. 2001. Mol Pharmacol. 59: 24-9. PMID: 11125020
  4. Agmatine signaling: odds and threads.  |  Berkels, R., et al. 2004. Cardiovasc Drug Rev. 22: 7-16. PMID: 14978515
  5. Regulation of inducible nitric oxide synthase and agmatine synthesis in macrophages and astrocytes.  |  Regunathan, S. and Piletz, JE. 2003. Ann N Y Acad Sci. 1009: 20-9. PMID: 15028566
  6. Agmatine: at the crossroads of the arginine pathways.  |  Satriano, J. 2003. Ann N Y Acad Sci. 1009: 34-43. PMID: 15028568
  7. N-Methyl-d-Aspartate (NMDA) Receptor Blockade Prevents Neuronal Death Induced by Zika Virus Infection.  |  Costa, VV., et al. 2017. mBio. 8: PMID: 28442607
  8. Agmatine: an endogenous clonidine-displacing substance in the brain.  |  Li, G., et al. 1994. Science. 263: 966-9. PMID: 7906055
  9. Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine.  |  Galea, E., et al. 1996. Biochem J. 316 (Pt 1): 247-9. PMID: 8645212
  10. Selective inhibition of inducible nitric oxide synthase by agmatine.  |  Auguet, M., et al. 1995. Jpn J Pharmacol. 69: 285-7. PMID: 8699639

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Agmatine sulfate, 100 mg

sc-202920
100 mg
$69.00

Agmatine sulfate, 500 mg

sc-202920A
500 mg
$178.00