AFP/Alpha fetoprotein Antibody (39): sc-130302

AFP Antibody (39) is a mouse monoclonal IgG1 kappa light chain antibody designed to detect Alpha-fetoprotein (AFP), also known as Alpha 1 Fetoprotein or Alpha-fetoglobulin, with exceptional affinity for recombinant human AFP. Anti-AFP antibody (39) is validated for use in western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA), ensuring reliable detection of AFP across mouse, rat, and human samples. AFP is a critical glycoprotein predominantly synthesized in the fetal liver, where AFP plays a vital role in transporting essential ligands such as copper, nickel, and fatty acids, as well as interacting with proteins like serum albumin and estrogen receptors. These interactions are crucial for maintaining physiological balance during development and for the regulation of cell growth and differentiation. In adult tissues, AFP levels are typically minimal; however, elevated AFP is a significant biomarker for hepatocellular carcinoma and other liver-related cancers, making AFP monoclonal antibody (39) an indispensable tool for early cancer detection and monitoring tumor progression. Additionally, AFP interacts with various transcription factors, including NF-1 and HNF-1, which regulate AFP expression and are involved in critical cellular pathways. The ability of AFP to bind with these proteins underscores AFP′s multifunctional nature and importance in both normal physiology and disease states. Anti-AFP antibody (39) is available in both non-conjugated form and multiple conjugated variants, including horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates, providing versatility for diverse experimental requirements.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-AFP/Alpha fetoprotein Antibody (39) has 18 citations in a variety of scientific publications.

Primary antibodies like Anti-AFP/Alpha fetoprotein Antibody (39) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

AFP/Alpha fetoprotein Antibody (39) Specifications

Alternate Product Name: AFP

Product Clone Name: 39

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: AFP

Epitope Species: human

Product Reactivity/Detection: AFP

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 18 citations in various scientific publications

Available Conjugates/Forms for AFP/Alpha fetoprotein Antibody (39): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred AFP/Alpha fetoprotein antibody is AFP/Alpha fetoprotein Antibody (C3): sc-8399.